Frank is a German surname. Notable persons with the surname include:

In art

• Alyce Frank (born 1932), American artist
• Jane Frank (1918–1986), American artist
• Jean-Michel Frank (1895–1941), French furniture and interior designer
• Leonard Frank (1870–1944), German-Canadian photographer
• Magda Frank (1914–2010), Hungarian-Argentine sculptor
• Mary Frank (born 1933), American artist
• Robert Frank (1924–2019), American photographer

In music

• Alan Frank (1910–1994), music publisher, clarinetist and composer
• Bob Frank (1944–2019), American musician, singer, and song writer
• Jackson C. Frank (1943–1999), American folk musician

In literature

• Anne Frank (1929–1945), author of a famous diary during World War II
  • Edith Frank (1900–1945), mother of Anne Frank
  • Margot Frank (1926–1945), sister of Anne Frank
  • Otto Frank (1889–1980), father of Anne Frank and posthumous editor of her works
• Bernard Frank (1929–2006), French journalist and writer
• Bruno Frank (1878–1945), German author, poet, dramatist and humanist
• Dan Frank (1954–2021), American editorial director at Pantheon Books
• Leonhard Frank (1882–1961), German writer
• Nathaniel Frank (fl. 2000s), American author and historian
• Waldo Frank (1889–1967), American author and scholar
• Thomas Frank (born 1965), American political analyst, historian, and writer

In military

• Bernhard Frank (1913–2011), German SS Commander
• Hans Frank (1900–1946), governor general of Nazi-occupied Poland
• Johann Frank (general) (born 1969) is an officer of the Austrian Armed Forces and political scientist
• Karl Hermann Frank (1898–1946), Sudeten-German Nazi official in Czechoslovakia

In politics

• Barney Frank (born 1940), American politician, Massachusetts Democratic congressperson
• Donald J. Frank (1937–1995), American politician from Minnesota
• James Frank (born 1966), American politician, Republican member of the Texas House of Representatives from Wichita Falls
• Josip Frank (1844–1911), Croatian lawyer and politician of Jewish descent
• Michael Frank (1804–1894), American politician from Wisconsin
• William J. Frank (born 1960), American politician, Maryland Republican state congressperson since 2003

In science

• Adolph Frank (1834–1916), German chemist
• Albert Bernhard Frank (1839–1900), German biologist
• András Frank (born 1949), Hungarian mathematician
• Dawn Frank, American biologist and academic administrator
• Frederick Charles Frank (1911–1998), British physicist, crystallographer
• Johann Peter Frank (1745–1821), German physician and hygienist
• Ilya Frank (1908–1990), physicist and 1958 Nobel laureate
• Philipp Frank (1884–1966), physicist, mathematician and philosopher
• Dr. Nicholas Frank, English-American Veterinarian and Dean of Mississippi State University College of Veterinary Medicine
• Christienne Frank (1961-) Aerospace Engineer

In sports

• John Frank (tight end) (born 1962), American NFL football player
• Thomas Frank (football manager) (born 1973), Danish football manager
• Tommy Frank (born 1993), British boxer
• Wolfgang Frank (1951–2013), German footballer and manager

Other

• Andre Gunder Frank (1929–2005), German-American sociologist known as a founder of dependency theory
• Bernard Frank (wilderness activist) (1902–1964), wilderness activist and co-founder of The Wilderness Society
• Donovan W. Frank (born 1951), American judge
• Eugene Maxwell Frank (1907–2009), American Bishop of the Methodist and United Methodist Churches
• Eve Frank (1754–1816/1817), female Jewish messiah claimant
• Harriet Frank Jr. (1923–2020), American screenwriter and film producer
• Helmar Frank (1933–2013), German mathematician and educator
• Henry Frank (1851–1908), Montana entrepreneur
• Jacob Frank (1726–1791), Polish founder of a Jewish dissident sect
• Jason David Frank (1973–2022), American actor
• Jerome Frank (1889–1957), American legal philosopher and judge
• Leo Frank (1884–1915), man convicted of murdering a 13-year-old girl in Georgia
• Lisa Frank (born 1955), American businesswoman
• Peter Frank (academic) (1934–2013), British professor and media commentator
• Peter Frank (art critic) (born 1950), art critic, curator, and poet
• Ray Frank (1861–1948), female Jewish religious leader
• Robert Frank (1924–2019), photographer
• Robert H. Frank (born 1945), economist
• Semyon Frank, (1877–1950) Russian philosopher
• Peirson Frank (1881–1951), British civil engineer
• Ulrich Frank (born 1958), German computer scientist