Frank Seno
No. 25
Seno on a 1948 Bowman football card
Date of birth(1921-02-15)February 15, 1921
Place of birthMendota, Illinois, U.S.
Place of deathBellwood, Illinois, U.S.
Career information
Position(s)Running back
Defensive back
US collegeGeorge Washington
Career history
As player
1943–1944Washington Redskins
1945–1946Chicago Cardinals
1947–1948Boston Yanks
1949Washington Redskins
Career stats

Frank Seno (February 15, 1921 – March 1974) was an American football running back and defensive back in the National Football League (NFL) for the Washington Redskins, the Chicago Cardinals, and the Boston Yanks. He attended George Washington University.