Frankel is a surname. Notable people with the surname include:

• Benjamin Frankel (1906–1973), British composer
• Bethenny Frankel (born 1970), American chef and reality television personality
• Charles Frankel (1917–1975), American philosopher, known for Charles Frankel Prize
• Cyril Frankel (1921–2017), British director
• Dan Frankel (American politician) (born 1956), member of the Pennsylvania House of Representatives
• Dan Frankel (British politician) (1900–1988), MP for Mile End, 1935–1945
• Dave Frankel, American attorney, former television weatherman and news anchor
• David Frankel (born 1959), American director, editor, screenwriter, executive producer
• Felice Frankel, American photographer of scientific art images, or artistic science images.
• Gene Frankel (1919–2005), American theater director
• Jacob Frankel (1808–1887), German-born American rabbi
• Jeffrey Frankel (born 1952), American economist
• Jerry Frankel (1930–2018), American musical theatre producer and thoroughbred breeder and owner
• Jonah Frankel (1928–2012), author, Hebrew literature professor and Israel Prize laureate
• Jonah Frankel (businessman) (died 1846), German Jewish businessman, banker and philanthropist
• Jonah Teomim-Frankel (1595–1669), author of the book Kikayon deYona
• Joseph Frankel (musician) (1882–1956), American army band and klezmer bandleader
• Justin Frankel (born 1978), American computer programmer
• Lee K. Frankel (1867–1931), American social worker and insurance executive
• Leó Frankel (1844–1896), Hungarian politician
• Lois Frankel (born 1948), member of the United States House of Representatives from Florida
• Martin Frankel (born 1954), American financier
• Max Frankel (born 1930), American journalist and former New York Times executive editor
• Naomi Frankel (1918–2009), German-Israeli novelist
• Otto Frankel (Otto Herzberg Frankel; 1900–1998), Australian biologist and geneticist of Austrian descent
• Richard B. Frankel, American physicist
• Robert "Bobby" J. Frankel (1941–2009), American thoroughbred race horse trainer
• Sandra Frankel (born 1941), former supervisor of the Town of Brighton, Monroe County, New York
• Susannah Frankel, British fashion journalist and author
• Susy Frankel, New Zealand law academic
• Stan Frankel (1919–1978), American physicist
• Theodore Frankel (1929–2017), American mathematician
• Tomer Frankel (born 2000), Israeli swimmer, European 2018 junior champion in the 100 m freestyle
• William Frankel (1903–2008), editor of the British weekly newspaper, The Jewish Chronicle, from 1958 to 1977
• Zecharias Frankel (1801–1875), Bohemian-German conservative rabbi, historian