Fungal pheromone mating factor STE2 GPCR
Structure of a Peptide Segment of the 6th Transmembrane Domain of the Saccharomyces cerevisiae alpha-Factor Receptor.[1]
Identifiers
SymbolSTE2
PfamPF02116
InterProIPR000366
SCOP21pjd / SCOPe / SUPFAM
OPM superfamily6
OPM protein2k9p
CDDcd14939
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
PDB1pjdA:253-269

Fungal pheromone mating factor receptors form a distinct family of G-protein-coupled receptors.

Function

Mating factor receptors STE2 and STE3 are integral membrane proteins that may be involved in the response to mating factors on the cell membrane.[2][3][4] The amino acid sequences of both receptors contain high proportions of hydrophobic residues grouped into 7 domains, in a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins.

References

  1. ^ Valentine KG, Liu SF, Marassi FM, et al. (October 2001). "Structure and topology of a peptide segment of the 6th transmembrane domain of the Saccharomyces cerevisiae alpha-factor receptor in phospholipid bilayers". Biopolymers. 59 (4): 243–56. doi:10.1002/1097-0282(20011005)59:4<243::AID-BIP1021>3.0.CO;2-H. PMC 3282060. PMID 11473349.
  2. ^ Nakayama N, Miyajima A, Arai K (1985). "Nucleotide sequences of STE2 and STE3, cell type-specific sterile genes from Saccharomyces cerevisiae". EMBO J. 4 (10): 2643–2648. doi:10.1002/j.1460-2075.1985.tb03982.x. PMC 554555. PMID 16453635.
  3. ^ Burkholder AC, Hartwell LH (1985). "The yeast alpha-factor receptor: structural properties deduced from the sequence of the STE2 gene". Nucleic Acids Res. 13 (23): 8463–8475. doi:10.1093/nar/13.23.8463. PMC 322145. PMID 3001640.
  4. ^ Herskowitz I, Marsh L (1988). "STE2 protein of Saccharomyces kluyveri is a member of the rhodopsin/beta-adrenergic receptor family and is responsible for recognition of the peptide ligand alpha factor". Proc. Natl. Acad. Sci. U.S.A. 85 (11): 3855–3859. Bibcode:1988PNAS...85.3855M. doi:10.1073/pnas.85.11.3855. PMC 280318. PMID 2836861.


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