GABRA6
Identifiers
AliasesGABRA6, gamma-aminobutyric acid type A receptor alpha6 subunit, gamma-aminobutyric acid type A receptor subunit alpha6
External IDsOMIM: 137143 MGI: 95618 HomoloGene: 20220 GeneCards: GABRA6
Orthologs
SpeciesHumanMouse
Entrez

2559

14399

Ensembl

ENSG00000145863

ENSMUSG00000020428

UniProt

Q16445

P16305

RefSeq (mRNA)

NM_000811

NM_001099641
NM_008068
NM_001359049

RefSeq (protein)

NP_000802

NP_001093111
NP_032094
NP_001345978

Location (UCSC)Chr 5: 161.55 – 161.7 MbChr 11: 42.31 – 42.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gamma-aminobutyric acid receptor subunit alpha-6 is a protein that in humans is encoded by the GABRA6 gene.[5][6]

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.[6]

One study found a genetic variant in the gene to be associated with the personality trait neuroticism.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145863 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020428 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hicks AA, Bailey ME, Riley BP, Kamphuis W, Siciliano MJ, Johnson KJ, Darlison MG (Aug 1994). "Further evidence for clustering of human GABAA receptor subunit genes: localization of the alpha 6-subunit gene (GABRA6) to distal chromosome 5q by linkage analysis". Genomics. 20 (2): 285–288. doi:10.1006/geno.1994.1167. PMID 8020978.
  6. ^ a b "Entrez Gene: GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6".
  7. ^ Srijan Sen; Sandra Villafuerte; Randolph Nesse; Scott F. Stoltenberg; Jeffrey Hopcian; Lillian Gleiberman; Alan Weder & Margit Burmeister (February 2004). "Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism". Biological Psychiatry. 55 (3): 244–249. doi:10.1016/j.biopsych.2003.08.006. PMID 14744464. S2CID 7244510.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Ion channel, cell surface receptor: ligand-gated ion channels
GABA receptor modulators
Categories