GAF domain | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
Symbol | GAF | ||||||||
Pfam | PF01590 | ||||||||
Pfam clan | CL0161 | ||||||||
InterPro | IPR003018 | ||||||||
SMART | GAF | ||||||||
SCOP2 | 1fl4 / SCOPe / SUPFAM | ||||||||
|
The GAF domain is a type of protein domain that is found in a wide range of proteins from all species.[2] The GAF domain is named after some of the proteins it is found in: cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. The first structure of a GAF domain solved by Ho and colleagues showed that this domain shared a similar fold with the PAS domain.[3] In mammals, GAF domains are found in five members of the cyclic nucleotide phosphodiesterase superfamily: PDE2, PDE5, and PDE6 which bind cGMP to the GAF domain, PDE10 which binds cAMP, and PDE11 which binds both cGMP and cAMP.[4][5]
Human proteins containing this domain include: