GEM
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CJW, 2G3Y, 2HT6
Identifiers
Aliases	GEM, KIR, GTP binding protein overexpressed in skeletal muscle
External IDs	OMIM: 600164 MGI: 99844 HomoloGene: 38024 GeneCards: GEM
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q22.1 Start 94,249,253 bp[1] End 94,262,350 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 A1|4 5.34 cM Start 11,704,457 bp[2] End 11,714,752 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium gallbladder vena cava gastric mucosa right coronary artery ascending aorta mucosa of urinary bladder secondary oocyte saphenous vein left uterine tube Top expressed in ascending aorta cumulus cell aortic valve pineal gland adrenal gland endocardial cushion spermatocyte atrioventricular valve islet of Langerhans left lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding protein binding magnesium ion binding calmodulin binding GDP binding GTPase activity calcium channel regulator activity Cellular component spindle midzone cytoplasmic side of plasma membrane plasma membrane midbody mitotic spindle nucleus membrane Biological process cell surface receptor signaling pathway metaphase plate congression chromosome organization immune response signal transduction mitotic cell cycle negative regulation of high voltage-gated calcium channel activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2669 14579 Ensembl ENSG00000164949 ENSMUSG00000028214 UniProt P55040 P55041 RefSeq (mRNA) NM_181702 NM_005261 NM_010276 RefSeq (protein) NP_005252 NP_859053 NP_034406 Location (UCSC) Chr 8: 94.25 – 94.26 Mb Chr 4: 11.7 – 11.71 Mb PubMed search [3] [4]
Wikidata
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GTP-binding protein GEM is a protein that in humans is encoded by the GEM gene.^[5][6][7]

The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.^[7]