GFI1
Identifiers
Aliases	GFI1, GFI-1, GFI1A, SCN2, ZNF163, growth factor independent 1 transcriptional repressor
External IDs	OMIM: 600871 MGI: 103170 HomoloGene: 3854 GeneCards: GFI1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p22.1 Start 92,473,043 bp[1] End 92,486,925 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 F|5 52.23 cM Start 107,864,523 bp[2] End 107,873,902 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow bone marrow cells spongy bone body of pancreas thymus blood lymph node spleen appendix rectum Top expressed in utricle thymus saccule spermatocyte bone marrow tongue crypt of lieberkuhn of small intestine Paneth cell extensor digitorum longus muscle organ of Corti More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding metal ion binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity Cellular component nuclear body nuclear matrix transcription repressor complex nucleus nucleoplasm Biological process positive regulation of interleukin-6-mediated signaling pathway negative regulation of neuron projection development regulation of transcription, DNA-templated regulation of toll-like receptor signaling pathway regulation of histone H3-K4 methylation negative regulation of transcription by RNA polymerase II regulation of transcription involved in G1/S transition of mitotic cell cycle transcription, DNA-templated negative regulation of vitamin D biosynthetic process negative regulation of calcidiol 1-monooxygenase activity viral process negative regulation of transcription, DNA-templated negative regulation of NF-kappaB transcription factor activity cellular response to lipopolysaccharide hemopoiesis positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2672 14581 Ensembl ENSG00000162676 ENSMUSG00000029275 UniProt Q99684 P70338 RefSeq (mRNA) NM_001127215 NM_001127216 NM_005263 NM_001267621 NM_010278 RefSeq (protein) NP_001120687 NP_001120688 NP_005254 NP_001254550 NP_034408 Location (UCSC) Chr 1: 92.47 – 92.49 Mb Chr 5: 107.86 – 107.87 Mb PubMed search [3] [4]
Wikidata
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Zinc finger protein Gfi-1 is a transcriptional repressor that in humans is encoded by the GFI1 gene.^[5] It is important normal hematopoiesis.^[6]

Interactions

GFI1 has been shown to interact with PIAS3^[7] and RUNX1T1.^[8]