GJB5
Identifiers
Aliases	GJB5, CX31.1, gap junction protein beta 5
External IDs	OMIM: 604493 MGI: 95723 HomoloGene: 3858 GeneCards: GJB5
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.3 Start 34,755,047 bp[1] End 34,758,512 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.2|4 61.51 cM Start 127,248,602 bp[2] End 127,251,974 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen gums epithelium of esophagus cavity of mouth palpebral conjunctiva vagina vulva cervix epithelium nipple human penis Top expressed in lip skin of back skin of abdomen epidermis hair follicle morula left colon esophagus yolk sac cornea More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 2709 14622 Ensembl ENSG00000189280 ENSMUSG00000042357 UniProt O95377 Q02739 RefSeq (mRNA) NM_005268 NM_010291 RefSeq (protein) NP_005259 NP_034421 Location (UCSC) Chr 1: 34.76 – 34.76 Mb Chr 4: 127.25 – 127.25 Mb PubMed search [3] [4]
Wikidata
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Gap junction beta-5 protein (GJB5), also known as connexin-31.1 (Cx31.1), is a protein that in humans is encoded by the GJB5 gene.^[5]

Function

Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family.^[5]