Available structures
PDBOrtholog search: PDBe RCSB
AliasesGNAI3, 87U6, ARCND1, G protein subunit alpha i3, HG1A
External IDsOMIM: 139370 MGI: 95773 HomoloGene: 55975 GeneCards: GNAI3
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 1: 109.55 – 109.6 MbChr 3: 108.01 – 108.05 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Guanine nucleotide-binding protein G(k) subunit alpha is a protein that in humans is encoded by the GNAI3 gene.[5][6]


GNAI3 has been shown to interact with:

See also


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000065135Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000001Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Didsbury JR, Snyderman R (Jul 1987). "Molecular cloning of a new human G protein. Evidence for two Gi alpha-like protein families". FEBS Letters. 219 (1): 259–63. doi:10.1016/0014-5793(87)81228-0. PMID 3109953. S2CID 85219415.
  6. ^ "Entrez Gene: GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3".
  7. ^ Hunt TW, Fields TA, Casey PJ, Peralta EG (Sep 1996). "RGS10 is a selective activator of G alpha i GTPase activity". Nature. 383 (6596): 175–7. Bibcode:1996Natur.383..175H. doi:10.1038/383175a0. PMID 8774883. S2CID 4318445.
  8. ^ a b Kimple RJ, De Vries L, Tronchère H, Behe CI, Morris RA, Gist Farquhar M, Siderovski DP (Aug 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". The Journal of Biological Chemistry. 276 (31): 29275–81. doi:10.1074/jbc.M103208200. PMID 11387333.
  9. ^ a b Chen C, Zheng B, Han J, Lin SC (Mar 1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". The Journal of Biological Chemistry. 272 (13): 8679–85. doi:10.1074/jbc.272.13.8679. PMID 9079700.
  10. ^ Beadling C, Druey KM, Richter G, Kehrl JH, Smith KA (Mar 1999). "Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes". Journal of Immunology. 162 (5): 2677–82. doi:10.4049/jimmunol.162.5.2677. PMID 10072511.
  11. ^ Yowe D, Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, Yu K, Faron L, Shen M, Cleary J, Wilkie TM, Gutierrez-Ramos C, Hodge MR (Oct 2001). "RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes". The Biochemical Journal. 359 (Pt 1): 109–18. doi:10.1042/bj3590109. PMC 1222126. PMID 11563974.
  12. ^ Gagnon AW, Murray DL, Leadley RJ (Jul 2002). "Cloning and characterization of a novel regulator of G protein signalling in human platelets". Cellular Signalling. 14 (7): 595–606. doi:10.1016/s0898-6568(02)00012-8. PMID 11955952.
  13. ^ De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG (Dec 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proceedings of the National Academy of Sciences of the United States of America. 93 (26): 15203–8. Bibcode:1996PNAS...9315203D. doi:10.1073/pnas.93.26.15203. PMC 26381. PMID 8986788.
  14. ^ Woulfe DS, Stadel JM (Jun 1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". The Journal of Biological Chemistry. 274 (25): 17718–24. doi:10.1074/jbc.274.25.17718. PMID 10364213.
  15. ^ De Vries L, Mousli M, Wurmser A, Farquhar MG (Dec 1995). "GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain". Proceedings of the National Academy of Sciences of the United States of America. 92 (25): 11916–20. Bibcode:1995PNAS...9211916D. doi:10.1073/pnas.92.25.11916. PMC 40514. PMID 8524874.
  16. ^ Zhou J, Moroi K, Nishiyama M, Usui H, Seki N, Ishida J, Fukamizu A, Kimura S (Feb 2001). "Characterization of RGS5 in regulation of G protein-coupled receptor signaling". Life Sciences. 68 (13): 1457–69. doi:10.1016/s0024-3205(01)00939-0. PMID 11253162.
  17. ^ Tall GG, Krumins AM, Gilman AG (Mar 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". The Journal of Biological Chemistry. 278 (10): 8356–62. doi:10.1074/jbc.M211862200. PMID 12509430.
  18. ^ Lee MJ, Evans M, Hla T (May 1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway". The Journal of Biological Chemistry. 271 (19): 11272–9. doi:10.1074/jbc.271.19.11272. PMID 8626678.

Further reading