GNAL
Identifiers
AliasesGNAL, DYT25, G protein subunit alpha L, HG1O
External IDsOMIM: 139312 MGI: 95774 HomoloGene: 68222 GeneCards: GNAL
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_010307
NM_177137

RefSeq (protein)

NP_001135811
NP_001248372
NP_001248373
NP_892023
NP_001356316

NP_034437
NP_796111

Location (UCSC)Chr 18: 11.69 – 11.89 MbChr 18: 67.09 – 67.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Guanine nucleotide-binding protein G(olf) subunit alpha is a protein that in humans is encoded by the GNAL gene.[5][6] Its main product is the heterotrimeric G-protein alpha subunit Golf-α, a member of the Gs alpha subunit family that is a key component of G protein-coupled receptor-regulated adenylyl cyclase signal transduction pathways in the olfactory system and the striatum in the brain. It also mediated D1 receptor signalling in the striatum and is hence involved in motor control.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000141404 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024524 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg JR, Trask BJ, de Jong P, Reed RR, Simon MI, et al. (Jun 1993). "Evolution of the mammalian G protein alpha subunit multigene family". Nat Genet. 1 (2): 85–91. doi:10.1038/ng0592-85. PMID 1302014. S2CID 31888533.
  6. ^ "Entrez Gene: GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type".
  7. ^ Zhuang, Xiaoxi; Belluscio, Leonardo; Hen, Rene (15 August 2000). "GOLFα Mediates Dopamine D 1 Receptor Signaling". The Journal of Neuroscience. 20 (16): RC91. doi:10.1523/JNEUROSCI.20-16-j0001.2000. PMC 6772608. PMID 10924528.

Further reading