POLR2M
Identifiers
Aliases	POLR2M, GCOM1, GRINL1A, Gdown, Gdown1, polymerase (RNA) II subunit M, RNA polymerase II subunit M
External IDs	OMIM: 606485 MGI: 107282 HomoloGene: 9181 GeneCards: POLR2M
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q21.3 Start 57,706,695 bp[1] End 57,782,762 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 D|9 39.85 cM Start 71,385,719 bp[2] End 71,393,217 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium Achilles tendon secondary oocyte vena cava optic nerve biceps brachii endometrium seminal vesicula vastus lateralis muscle parietal pleura Top expressed in somite hand maxillary prominence foot abdominal wall primitive streak atrium dorsomedial hypothalamic nucleus entorhinal cortex superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-directed 5'-3' RNA polymerase activity protein binding Cellular component RNA polymerase II, holoenzyme neuronal cell body nuclear envelope nucleus cytoplasm cell junction plasma membrane Z disc cytoskeleton membrane I band cortical actin cytoskeleton extrinsic component of cytoplasmic side of plasma membrane intracellular anatomical structure Biological process maintenance of ER location RNA biosynthetic process intracellular signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81488 28015 Ensembl ENSG00000255529 ENSMUSG00000032199 UniProt P0CAP2 Q6EEV4 P0CAP1 Q6P6I6 RefSeq (mRNA) NM_001018102 NM_015532 NM_001164793 NM_178602 RefSeq (protein) NP_001018112 NP_056347 NP_001018112.1 NP_056347.1 NP_001018110 NP_689664 NP_001158265 NP_848717 Location (UCSC) Chr 15: 57.71 – 57.78 Mb Chr 9: 71.39 – 71.39 Mb PubMed search [3] [4]
Wikidata
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GRINL1A complex locus protein 1 is a protein that in humans is encoded by the GRINL1A gene.^[5]

This gene (GRINL1A) is part of a complex transcript unit that includes the gene for GRINL1A combined protein (Gcom1). Transcription of this gene occurs at a downstream promoter, with at least three different alternatively spliced variants, grouped together as Gdown for GRINL1A downstream transcripts. The Gcom1 gene uses an upstream promoter for transcription and also has multiple alternatively spliced variants.^[5]