GUCA1B
Identifiers
Aliases	GUCA1B, GCAP2, GUCA2, RP48, guanylate cyclase activator 1B, GCAP 2
External IDs	OMIM: 602275 MGI: 1194489 HomoloGene: 1586 GeneCards: GUCA1B
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.1 Start 42,183,284 bp[1] End 42,194,956 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 C Start 47,696,318 bp[2] End 47,703,892 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere tibialis anterior muscle gastrocnemius muscle stromal cell of endometrium tibial nerve spongy bone right uterine tube gastric mucosa canal of the cervix Brodmann area 23 Top expressed in quadriceps femoris muscle outer nuclear layer islet of Langerhans bone marrow zone of skin mirror esophagus urinary bladder jejunum duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding guanylate cyclase regulator activity metal ion binding calcium sensitive guanylate cyclase activator activity Cellular component photoreceptor inner segment membrane plasma membrane photoreceptor outer segment photoreceptor disc membrane Biological process phototransduction response to stimulus cell-cell signaling positive regulation of guanylate cyclase activity regulation of guanylate cyclase activity receptor guanylyl cyclase signaling pathway body fluid secretion visual perception regulation of rhodopsin mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2979 107477 Ensembl ENSG00000112599 ENSMUSG00000023979 UniProt Q9UMX6 Q8VBV8 RefSeq (mRNA) NM_002098 NM_146079 RefSeq (protein) NP_002089 NP_666191 Location (UCSC) Chr 6: 42.18 – 42.19 Mb Chr 17: 47.7 – 47.7 Mb PubMed search [3] [4]
Wikidata
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Guanylyl cyclase-activating protein 2 is an enzyme that in humans is encoded by the GUCA1B gene.^[5][6] Alternative names:^[7]

• Guanylate cyclase activator 1B
• Retinal guanylyl cyclase activator protein p24

Biological Role

Guanylyl cyclase-activating protein 2 is proposed to play a role in dark adaptation.^[8] Under scotopic conditions, calcium ions bind to three putative EF-hand calcium binding motifs which reduces the protein's ability to stimulate guanylyl cyclase.^[8] This contributes to the maintained responsiveness of rod photoreceptors through hyperpolarizing them during sustained darkness.