GNL3L
Identifiers
Aliases	GNL3L, GNL3B, G protein nucleolar 3 like
External IDs	OMIM: 300873 MGI: 2448557 HomoloGene: 134538 GeneCards: GNL3L
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.22 Start 54,530,183 bp[1] End 54,621,521 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X F3 Start 149,766,137 bp[2] End 149,800,318 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nipple sural nerve pylorus urethra bone marrow cells human penis renal medulla superior surface of tongue monocyte cavity of mouth Top expressed in dorsomedial hypothalamic nucleus paraventricular nucleus of hypothalamus ventral tegmental area habenula suprachiasmatic nucleus arcuate nucleus piriform cortex lateral hypothalamus dorsal tegmental nucleus mammillary body More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding nucleotide binding GTP binding RNA binding GTPase activity Cellular component nucleus telomerase holoenzyme complex membrane nucleolus cytosol Biological process regulation of protein stability negative regulation of telomere maintenance via telomerase positive regulation of protein homodimerization activity negative regulation of protein sumoylation positive regulation of protein localization to chromosome, telomeric region negative regulation of protein ubiquitination negative regulation of protein binding ribosome biogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54552 237107 Ensembl ENSG00000130119 ENSMUSG00000025266 UniProt Q9NVN8 Q6PGG6 RefSeq (mRNA) NM_001184819 NM_019067 NM_001168600 NM_198110 RefSeq (protein) NP_001171748 NP_061940 NP_001162071 NP_932778 Location (UCSC) Chr X: 54.53 – 54.62 Mb Chr X: 149.77 – 149.8 Mb PubMed search [3] [4]
Wikidata
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G protein nucleolar 3 like is a protein that in humans is encoded by the GNL3L gene.^[5]

Function

The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene.