Galanin-like peptide
Identifiers
SymbolGALP
NCBI gene85569
HGNC24840
OMIM611178
RefSeqNM_033106
UniProtQ9UBC7
Other data
LocusChr. 19 q13.42
Search for
StructuresSwiss-model
DomainsInterPro

Galanin-like peptide (GALP) is a neuropeptide present in humans and other mammals. It is a 60-amino acid polypeptide produced in the arcuate nucleus of the hypothalamus and the posterior pituitary gland.[1][2][3] It is involved in the regulation of appetite and may also have other roles such as in inflammation, sex behavior, and stress.[4][5][6][7][8][9]

Findings additionally suggest that GALP could play a function in energy metabolism due to its ability to maintain continual activation of the sympathetic nervous system (SNS) via thermogenesis, which refers to the production of heat within living organisms.[10] In addition, the administration of GALP directly into the brain leads to a reduction in the secretion of thyroid-stimulating hormone (TSH), which indicates the involvement of GALP in the neuroendocrine regulation of the hypothalamic-pituitary-thyroid (HPT) axis, and further adding to the evidence of the role of GALP in energy homeostasis.[11]

Notes

  1. ^ Seth A, Stanley S, Dhillo W, Murphy K, Ghatei M, Bloom S (February 2003). "Effects of galanin-like peptide on food intake and the hypothalamo-pituitary-thyroid axis". Neuroendocrinology. 77 (2): 125–31. doi:10.1159/000068648. PMID 12624534. S2CID 8589263.
  2. ^ Kageyama H, Takenoya F, Kita T, Hori T, Guan JL, Shioda S (March 2005). "Galanin-like peptide in the brain: effects on feeding, energy metabolism and reproduction". Regulatory Peptides. 126 (1–2): 21–6. doi:10.1016/j.regpep.2004.08.029. PMID 15620409. S2CID 26597732.
  3. ^ Kageyama H, Takenoya F, Hori Y, Yoshida T, Shioda S (January 2008). "Morphological interaction between galanin-like peptide- and dopamine-containing neurons in the rat arcuate nucleus". Regulatory Peptides. 145 (1–3): 165–8. doi:10.1016/j.regpep.2007.08.019. PMID 17916390. S2CID 40659877.
  4. ^ Man PS, Lawrence CB (July 2008). "Galanin-like peptide: a role in the homeostatic regulation of energy balance?". Neuropharmacology. 55 (1): 1–7. doi:10.1016/j.neuropharm.2008.04.008. PMID 18538801. S2CID 22168757.
  5. ^ Kuramochi M, Onaka T, Kohno D, Kato S, Yada T (April 2006). "Galanin-like peptide stimulates food intake via activation of neuropeptide Y neurons in the hypothalamic dorsomedial nucleus of the rat". Endocrinology. 147 (4): 1744–52. doi:10.1210/en.2005-0907. PMID 16410310.
  6. ^ Taylor A, Madison FN, Fraley GS (March 2009). "Galanin-like peptide stimulates feeding and sexual behavior via dopaminergic fibers within the medial preoptic area of adult male rats". Journal of Chemical Neuroanatomy. 37 (2): 105–11. doi:10.1016/j.jchemneu.2008.12.003. PMID 19124073. S2CID 205768330.
  7. ^ Man PS, Lawrence CB (November 2008). "Interleukin-1 mediates the anorexic and febrile actions of galanin-like Peptide". Endocrinology. 149 (11): 5791–802. doi:10.1210/en.2008-0252. PMC 3306896. PMID 18617619.
  8. ^ Lawrence CB (July 2009). "Galanin-like peptide modulates energy balance by affecting inflammatory mediators?". Physiology & Behavior. 97 (5): 515–9. doi:10.1016/j.physbeh.2009.02.041. PMID 19298833. S2CID 24305797.
  9. ^ Suzuki H, Onaka T, Dayanithi G, Ueta Y (June 2009). "Pathophysiological roles of galanin-like peptide in the hypothalamus and posterior pituitary gland". Pathophysiology. 17 (2): 135–140. doi:10.1016/j.pathophys.2009.03.007. PMID 19501488.
  10. ^ Shiba K, Kageyama H, Takenoya F, Shioda S (2010). "Galanin-like peptide and the regulation of feeding behavior and energy metabolism". The FEBS Journal. 277 (24): 5006–5013. doi:10.1111/j.1742-4658.2010.07933.x. PMID 21126314. S2CID 24097221.
  11. ^ Lawrence C, Fraley GS (2011). "Galanin-like peptide (GALP) is a hypothalamic regulator of energy homeostasis and reproduction". Frontiers in Neuroendocrinology. 32 (1): 1–9. doi:10.1016/j.yfrne.2010.06.001. PMC 2950899. PMID 20558195.


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