GALR1
Identifiers
Aliases	GALR1, GALNR, GALNR1, Galanin receptor 1
External IDs	OMIM: 600377 MGI: 1096364 HomoloGene: 74396 GeneCards: GALR1
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q23 Start 77,249,848 bp[1] End 77,277,900 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 E3|18 55.78 cM Start 82,410,505 bp[2] End 82,424,902 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pituitary gland anterior pituitary prefrontal cortex hypothalamus corpus callosum amygdala right uterine tube dorsolateral prefrontal cortex rectum superior frontal gyrus Top expressed in islet of Langerhans posterior horn of spinal cord trigeminal nerve supraoptic nucleus paraventricular nucleus of hypothalamus neural tube dorsomedial hypothalamic nucleus superior frontal gyrus rhombencephalon cerebellum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity neuropeptide binding signal transducer activity peptide hormone binding galanin receptor activity protein binding G protein-coupled peptide receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane intracellular anatomical structure Biological process positive regulation of cortisol secretion negative regulation of adenylate cyclase activity adenylate cyclase-activating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of transcription by RNA polymerase II signal transduction neuropeptide signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2587 14427 Ensembl ENSG00000166573 ENSMUSG00000024553 UniProt P47211 P56479 RefSeq (mRNA) NM_001480 NM_008082 RefSeq (protein) NP_001471 NP_032108 Location (UCSC) Chr 18: 77.25 – 77.28 Mb Chr 18: 82.41 – 82.42 Mb PubMed search [3] [4]
Wikidata
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Galanin receptor 1 (GAL₁) is a G-protein coupled receptor encoded by the GALR1 gene.^[5]

Function

The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-trans membrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the GI/GO family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart.^[5]