GEMIN5
Identifiers
Aliases	GEMIN5, GEMIN-5, gem nuclear organelle associated protein 5, NEDCAM
External IDs	OMIM: 607005 MGI: 2449311 HomoloGene: 9155 GeneCards: GEMIN5
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.2 Start 154,887,411 bp[1] End 154,938,211 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 58,010,828 bp[2] End 58,059,365 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte tibialis anterior muscle deltoid muscle biceps brachii gastrocnemius muscle quadriceps femoris muscle Achilles tendon vastus lateralis muscle islet of Langerhans Top expressed in spermatocyte spermatid seminiferous tubule internal carotid artery morula intestinal villus external carotid artery primitive streak maxillary prominence abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function snRNA binding protein binding RNA 7-methylguanosine cap binding mRNA 3'-UTR binding U1 snRNA binding U4 snRNA binding U4atac snRNA binding ribosome binding RNA binding Cellular component cytoplasm SMN complex SMN-Sm protein complex cytosol nuclear body membrane gemini of coiled bodies nucleoplasm nucleus cytosolic large ribosomal subunit SMN-Gemin2 complex Biological process mRNA splicing, via spliceosome mRNA processing RNA splicing spliceosomal snRNP assembly import into nucleus protein biosynthesis regulation of translation protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25929 216766 Ensembl ENSG00000082516 ENSMUSG00000037275 UniProt Q8TEQ6 Q8BX17 RefSeq (mRNA) NM_015465 NM_001252156 NM_001166669 NM_001166670 NM_001166671 NM_172558 NM_001374702 RefSeq (protein) NP_001239085 NP_056280 NP_001160141 NP_001160142 NP_001160143 NP_766146 NP_001361631 Location (UCSC) Chr 5: 154.89 – 154.94 Mb Chr 11: 58.01 – 58.06 Mb PubMed search [3] [4]
Wikidata
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Gem-associated protein 5 is a protein that in humans is encoded by the GEMIN5 gene.^[5][6]

Function

Gem-associated protein 5 is part of the SMN a large protein complex localized to both the cytoplasm and the nucleus that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), gem-associated protein 2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), and GEMIN4 (MIM 606969).^[6]

Interactions

GEMIN5 has been shown to interact with DDX20^[5][7] and SMN1.^[5]