Gemazocine structure.svg
Clinical data
ATC code
  • None
  • 10-(cyclopropylmethyl)-1-ethyl-13,13-dimethyl-10-azatricyclo[,7]trideca-2,4,6-trien-4-ol
CAS Number
PubChem CID
Chemical and physical data
Molar mass299.458 g·mol−1
3D model (JSmol)
  • Oc1ccc4c(c1)C2(C(C(N(CC2)CC3CC3)C4)(C)C)CC
  • InChI=1S/C20H29NO/c1-4-20-9-10-21(13-14-5-6-14)18(19(20,2)3)11-15-7-8-16(22)12-17(15)20/h7-8,12,14,18,22H,4-6,9-11,13H2,1-3H3

Gemazocine (R-15,497), also known as cyclogemine, is a non-selective opioid antagonist of the benzomorphan class.[1][2][3] It may have partial agonist properties at some of the opioid receptors, such as at the kappa receptor (as it induces dysphoric effects in humans), but seems to be generally antagonistic in its actions.[4]


  1. ^ Macdonald, F. (1997). Dictionary of Pharmacological Agents. CRC Press. p. 955. ISBN 978-0-412-46630-4. Retrieved 22 April 2012.
  2. ^ Gelders, Y. G.; de Ranter, C. J.; Schenk, H. (1979). "Structural Studies of Substituted 6,7-Benzomorphan Compounds. I. The Absolute Configuration of (−)-2-Cyclopropylmethyl-2'-hydroxy-5-ethyl-9,9-dimethyl-6,7-benzomorphan (Gemazocine) Hydrobromide". Acta Crystallographica B. 35 (3): 699–703. doi:10.1107/S0567740879004477.((cite journal)): CS1 maint: uses authors parameter (link)
  3. ^ Verlinde C, De Ranter C (August 1988). "Assessment of the kappa-opioid activity of a series of 6,7-benzomorphans in the rabbit vas deferens". Eur. J. Pharmacol. 153 (1): 83–7. doi:10.1016/0014-2999(88)90590-0. PMID 2850928.
  4. ^ Freye, E.; Hartung, E.; Schenk, G. K. (1983). "Bremazocine: An Opiate That Induces Sedation and Analgesia without Respiratory Depression" (PDF). Anesthesia and Analgesia. 62 (5): 483–488. doi:10.1213/00000539-198305000-00005. PMID 6301311.