George Clarke (1661–1736) was a British Judge Advocate General, Secretary at War, Lord Commissioner of the Admiralty.

George Clarke may also refer to:

Arts and entertainment

• George Clarke (filmmaker), film director from Northern Ireland
• George Elliott Clarke (born 1960), Canadian poet and playwright
• George Clarke (architect) (born 1974), British architect and television presenter
• George Clarke (handyman), personality on the Late Show with David Letterman
• George Somers Leigh Clarke (1822–1882), English architect
• George Clarke (singer), lead singer of Deafheaven
• George Clarke (jazz musician) (1911–1985), American jazz saxophonist
• George Clarke (actor) (1840–1906), American stage actor
• George Clarke (comedian) (1886–1946), English stage comedian

Politics

• George Clarke (governor) (1676–1760), colonial New York, 1736–1743
• George Clarke (New Zealand pioneer) (1823–1913), pioneer and educationist
• George Clarke, 1st Baron Sydenham of Combe (1848–1933), British colonial administrator
• George W. Clarke (Iowa politician) (1852–1936), governor of Iowa
• George W. Clarke (Newfoundland politician) (1910–2000), Newfoundland lawyer and politician
• George W. Clarke (Washington politician) (1906–2006), American politician in the state of Washington
• George Johnson Clarke (1857–1917), premier of New Brunswick
• George Clarke (Canadian politician) (1827–?), politician in Nova Scotia
• George Clarke (judge) (1798–1875), New Zealand missionary, teacher, public servant, politician and judge
• George J. F. Clarke (1774–1836), active in East Florida in the Second Spanish Period
• George L. Clarke (1813–1890), mayor of Providence, Rhode Island
• George Thomas Clarke (1853–1925), Australian local government politician

Sport

• George Clarke (cricketer) (1869–1955), English cricketer
• George Clarke (footballer, born 1894) (1894–1960), footballer for Crewe Alexandra and Stoke
• George Clarke (footballer, born 1900) (1900–1977), English football player (Aston Villa, Crystal Palace, QPR)
• George Clarke (footballer, born 1921) (1921–2011), English football player (Ipswich Town)
• George Clarke (winger) (fl. 1908–1910), English professional association footballer who played as a winger

Other

• George Clarke (1768–1835), New York landowner who commissioned the construction of Hyde Hall
• George Clarke (priest) (1793–1871), archdeacon of Antigua
• George Aubourne Clarke (died 1949), Scottish meteorologist
• George Clarke (prospector) (1846–1895), prospector in Queensland, Australia
• George Calvert Clarke (1814–1900), British Army officer
• George Frederick Clarke (1883–1974), New Brunswick author, historian and amateur archaeologist
• George Clarke (architect-planner) (1932–2005), Australian town planner during the 1970s
• George Marshall Clarke, African American barber in Milwaukee, Wisconsin, lynched in 1861
• George Clarke (convict) (1806–1835), convict and bushranger known as "The Barber"