Geraniol 8-hydroxylase
Identifiers
EC no.1.14.14.83
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Geraniol 8-hydroxylase (EC 1.14.14.83, Formerly EC 1.14.13.152, CYP76B6, G10H, CrG10H, SmG10H) is an enzyme with systematic name geraniol,NADPH:oxygen oxidoreductase (8-hydroxylating).[1][2][3] This enzyme catalyses the following chemical reaction

geraniol + NADPH + H+ + O2 (6E)-8-hydroxygeraniol + NADP+ + H2O

Geraniol 8-hydroxylase is a cytochrome P450 and therefore requires a partner cytochrome P450 reductase for functional expression.

References

  1. ^ Collu G, Unver N, Peltenburg-Looman AM, van der Heijden R, Verpoorte R, Memelink J (November 2001). "Geraniol 10-hydroxylase, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis". FEBS Letters. 508 (2): 215–20. doi:10.1016/s0014-5793(01)03045-9. PMID 11718718. S2CID 45615763.
  2. ^ Wang J, Liu Y, Cai Y, Zhang F, Xia G, Xiang F (2010). "Cloning and functional analysis of geraniol 10-hydroxylase, a cytochrome P450 from Swertia mussotii Franch". Bioscience, Biotechnology, and Biochemistry. 74 (8): 1583–90. doi:10.1271/bbb.100175. PMID 20699579. S2CID 26540510.
  3. ^ Sung PH, Huang FC, Do YY, Huang PL (May 2011). "Functional expression of geraniol 10-hydroxylase reveals its dual function in the biosynthesis of terpenoid and phenylpropanoid". Journal of Agricultural and Food Chemistry. 59 (9): 4637–43. doi:10.1021/jf200259n. PMID 21504162.

External links

Cytochromes, oxygenases: cytochrome P450 (Most belong to EC 1.14)
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