| Glycosyl hydrolases family 19 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 the refined crystal structure of an endochitinase from hordeum vulgare l. seeds to 1.8 angstroms resolution | |||||||||
| Identifiers | |||||||||
| Symbol | Glyco_hydro_19 | ||||||||
| Pfam | PF00182 | ||||||||
| Pfam clan | CL0037 | ||||||||
| InterPro | IPR000726 | ||||||||
| PROSITE | PDOC00620 | ||||||||
| SCOP2 | 2baa / SCOPe / SUPFAM | ||||||||
| CAZy | GH19 | ||||||||
| CDD | cd00325 | ||||||||
| |||||||||
In molecular biology, Glycoside hydrolase family 19 is a family of glycoside hydrolases EC 3.2.1., which are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[1][2][3] This classification is available on the CAZy web site,[4][5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[6][7] y[ _]9
Glycoside hydrolase family 19 CAZY GH_19 comprises enzymes with only one known activity; chitinase (EC 3.2.1.14).
Chitinases[8] are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Chitinases belong to glycoside hydrolase families 18 or 19.[9] Chitinases of family 19 (also known as classes IA or I and IB or II) are enzymes from plants that function in the defence against fungal and insect pathogens by destroying their chitin-containing cell wall. Class IA/I and IB/II enzymes differ in the presence (IA/I) or absence (IB/II) of a N-terminal chitin-binding domain. The catalytic domain of these enzymes consist of about 220 to 230 amino acid residues.
