Great Fire or The Great Fire may refer to:

Fires

• Great Fire of Rome (64 A.D.)
• Great Fire of North Walsham (1605)
• 1615 Great Fire of Wymondham
• Great fire of Meireki (1657)
• Great Fire of London (1666)
• Great Fire of Northampton (1675)
• Great Fire of Warwick (1694)
• Great Stockholm Fire of 1759
• Great fire of Tartu (1775)
• Great Fire of New York (1776)
• Great New Orleans Fire (1794)
• Great New Orleans Fire (1788)
• Great Fire of Bedford (1802)
• Great Fire of Stevenage (1807)
• Great Podil fire (1811)
• Great fire of Tirschenreuth (1814)
• Great Fire of Edinburgh (1824)
• Great Fire of New York (1835)
• Great fire of Hamburg (1842)
• Great New York City Fire of 1845
• Great Fire of Pittsburgh (1845)
• Great Fire of 1846
• Great Fire of Toronto (1849)
• Great Fire of 1852
• Great fire of Newcastle and Gateshead (1854)
• Great fire of Brisbane (1864)
• 1866 great fire of Portland, Maine
• Great Fire of Whitstable, 1869
• Great Chicago Fire (1871)
• Great Michigan Fire (1871)
• Great Boston Fire of 1872
• 1877 Great Fire of Saint John, New Brunswick
• Great Vancouver Fire (1886)
• Great Seattle Fire (1889)
• Great Baltimore Fire (1904)
• Great Fire of Toronto (1904)
• Great Fire of 1910
• Centre Block great fire (1916)
• Great Thessaloniki Fire of 1917
• Great fire of Smyrna (1922)
• Second Great Fire of London (1940)
• Great Fire of Valparaíso (2014)

Other uses

• The Great Fire (album), a 2012 album by Bleeding Through
• The Great Fire (Murphy novel), a 1995 novel by Jim Murphy about the Great Chicago Fire
• The Great Fire (TV series), a 2014 drama about the Great Fire of London
• The Great Fire (Hazzard novel), a 2003 novel by Shirley Hazzard
• The Great Fire (Vanity Fair), September 2020 issue of Vanity Fair guest-edited by Ta-Nehisi Coates and dedicated to topics of racial justice
• GreatFire, a non-profit organization monitoring internet censorship in China
• "Great Fire", a song by XTC from Mummer