Gregorio is a masculine given name and a surname. It may refer to:

Given name

• Gregorio Aglipay (1860–1940), Filipino revolutionary and first supreme bishop of the Philippine Independent Church
• Gregorio Conrado Álvarez (1925–2016), Uruguayan army general and de facto President of Uruguay from 1981 until 1985
• Gregorio Álvarez (historian) (1889–1986), Argentine historian, physician and writer
• Gregorio S. Araneta (1869–1930), Filipino lawyer, businessman and nationalist
• Gregorio Benito (1946–2020), Spanish retired footballer
• Gregorio C. Brillantes, Filipino writer
• Gregorio di Cecco (c. 1390–after 1424), Italian painter
• Gregório Nunes Coronel (c. 1548–c. 1620), Portuguese theologian, writer and preacher
• Gregorio Cortez (1875–1916), Mexican-American tenant farmer and folk hero
• Gregorio De Gregori (fl. 1496–1527), printer in Renaissance Venice
• Gregorio del Pilar (1875–1899), Philippine Revolutionary Forces general during the Philippine Revolution and the Philippine–American War
• Gregorio De Ferrari (c. 1647–1726), Italian painter
• Gregorio López (writer) (1895–1966), Mexican novelist, poet and journalist
• Gregorio López (handballer) (1951–1987), Spanish handball player
• Gregorio López (jurist) (1496–1560), president of the Council of the Indies
• Gregorio López-Bravo y Castro (1923–1985), Spanish politician, Minister of Foreign Affairs between 1969 and 1973
• Gregorio Luperón (1839–1897), Dominican military and political leader, President of the Dominican Republic from 1879 to 1880
• Gregorio Marañón (1887–1960), Spanish physician, scientist, historian, writer and philosopher
• Gregório de Matos (1636–1696), colonial Brazilian poet
• Gregorio Pérez (born 1948), Uruguayan football manager and former player
• Gregorio Petit (born 1984), Major League Baseball player from Venezuela
• Gregorio Ricci-Curbastro (1853–1925), Italian mathematician, inventor of tensor calculus
• Gregorio Salvador Caja (1927-2020), Spanish linguist
• Gregorio Manuel Salvador (born 1981), Equatoguinean footballer

Surname

• John T. Gregorio (1928−2013), American politician
• Mateus Gregório (born 1993), Brazilian weightlifter
• Rose Gregorio (born 1934), American actress
• Rossella Gregorio (born 1990), Italian sabre fencer