Grigorian or Grigoryan (Armenian: Գրիգորյան) is an Armenian surname. It is a patronym from the Armenian equivalent of Gregory and is the Eastern Armenian form of Krikorian.

It can refer to the following people:

• Armen Grigoryan (born 1960), Russian rock musician
• Artur Grigorian (born 1967), Uzbek boxer
• Artur Grigoryan (born 1985), Armenian football player
• Asmik Grigorian (born 1981), Lithuanian opera singer
• David Grigoryan (born 1982), Russian-Armenian former football player
• Gegham Grigoryan (1951–2016), Armenian opera singer
• Harut Grigorian (born 1989), Armenian-Belgian kickboxer
• Hambarsoom Grigorian (1893–1975), Iranian-Armenian composer and music professor
• Karen Grigorian (1947–1989), Armenian chess player
• Karen H. Grigoryan (born 1995), Armenian chess player
• Karen L. Grigorian (born 1968), Armenian diplomat
• Marcos Grigorian (1925–2007), Iranian-Armenian artist
• Mark Grigorian (1900–1978), Armenian neoclassical architect.
• Razmik Grigoryan (born 1971), Armenian football player
• The Grigoryan Brothers, Slava and Leonard (born 1976), Australian classical guitarists