Guinea-Bissau made its Paralympic Games debut by sending a delegation to compete at the 2012 Summer Paralympics in London, United Kingdom, having made its Olympic debut at 1996 Games. The delegation consisted of two athletes, Cesar Lopes Cardoso and Ussumane Cande, who both competed in track and field events. Neither athlete won a medal, with neither getting past the first round of their events.
Cesar Lopes Cardoso started competing in athletics in 2003.[5] He competed in the men's T46 400 metres, aged 31.[6] The T46 classification is an athlete who has, "Upper limb/s affected by limb deficiency, impaired muscle power or impaired range of movement."[7] In the event, Lopes Cardoso was drawn in heat one, a heat containing eventual gold medalist Günther Matzinger of Austria.[8] Lopes Cardoso ran a time of 55.08 seconds, a season's best for him, to finish last in the seven-man heat.[8] He was 5.17 seconds behind the heat winner, Matzinger, and 3.56 seconds behind the second-last finisher, Russian Alexey Kotlov.[8] Lopes Cardoso's was the slowest overall in the heat round and he did not progress to the final.[8]
Ussumane Cande was due to compete in two event at the 2012 Paralympics, the women's T46 100 metres and the women's T46 400 metres.[9] In the 100 metres, Cande raced in heat two on 4 September 2012.[10] In her race, Cande had a time 14.87 seconds, to finish last in her heat of six women.[10] Cande was 2.05 seconds behind the heat winner, Wang Yanping of China.[10] Cande's time was faster than only one other athlete in the heat round, Nepalese Maiya Bisunkhe who ran a time of 16.48 seconds.[10] Cande did not qualify for the final.[10] In the 400 metres, Cande was due to race in the final (the event had no heats) but did not; it was won by Cuban Yunidis Castillo.[11]
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