H1299, also known as NCI-H1299[1][2] or CRL-5803,[3] is a human non-small cell lung carcinoma cell line derived from the lymph node, which is widely used in research.[4]

As with other immortalized cell lines, H1299 cells can divide indefinitely. These cells have a homozygous partial deletion of the TP53 gene and as a result, do not express the tumor suppressor p53 protein which in part accounts for their proliferative propensity.[5] These cells have also been reported to secrete the peptide hormone neuromedin B (NMB), but not gastrin releasing peptide (GRP).[4]

References

  1. ^ "NCI-Navy Medical Oncology Branch cell line supplement". J. Cell. Biochem. Suppl. 24: 1–291. 1996. PMID 8965489.
  2. ^ "ATCC Advanced Catalog Search". Retrieved 2009-01-07.
  3. ^ "CRL-5803/NCI-H1299 cell line". LGC Promochem: Cell Biology Collection. American Type Culture Collection. Retrieved 2008-06-22.
  4. ^ a b Giaccone G, Battey J, Gazdar AF, Oie H, Draoui M, Moody TW (May 1992). "Neuromedin B is present in lung cancer cell lines". Cancer Res. 52 (9 Suppl): 2732s–2736s. PMID 1563005.
  5. ^ Lin DL, Chang C (June 1996). "p53 is a mediator for radiation-repressed human TR2 orphan receptor expression in MCF-7 cells, a new pathway from tumor suppressor to member of the steroid receptor superfamily". J. Biol. Chem. 271 (25): 14649–52. doi:10.1074/jbc.271.25.14649. PMID 8663350.

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