HLF
Identifiers
Aliases	HLF, PAR bZIP transcription factor, HLF transcription factor, PAR bZIP family member
External IDs	OMIM: 142385 MGI: 96108 HomoloGene: 31074 GeneCards: HLF
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q22 Start 55,264,960 bp[1] End 55,325,187 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 C|11 55.03 cM Start 90,227,362 bp[2] End 90,281,721 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon orbitofrontal cortex Brodmann area 46 superior frontal gyrus prefrontal cortex middle temporal gyrus postcentral gyrus Brodmann area 23 Brodmann area 9 occipital lobe Top expressed in lateral geniculate nucleus medial dorsal nucleus inferior colliculus medial geniculate nucleus primary motor cortex olfactory tubercle mammillary body pontine nuclei median eminence superior colliculus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process multicellular organism development skeletal muscle cell differentiation regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated rhythmic process positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3131 217082 Ensembl ENSG00000108924 ENSMUSG00000003949 UniProt Q16534 Q8BW74 RefSeq (mRNA) NM_002126 NM_001330375 NM_172563 RefSeq (protein) NP_001317304 NP_002117 NP_766151 NP_001390914 NP_001390915 NP_001390917 NP_001390918 NP_001390920 NP_001390922 NP_001390924 NP_001390926 Location (UCSC) Chr 17: 55.26 – 55.33 Mb Chr 11: 90.23 – 90.28 Mb PubMed search [3] [4]
Wikidata
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Hepatic leukemia factor is a protein that in humans is encoded by the HLF gene.^[5][6]

Function

This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.^[6]