HOPX
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UHS, 2HI3
Identifiers
Aliases	HOPX, CAMEO, HOD, HOP, LAGY, NECC1, OB1, SMAP31, TOTO, HOP homeobox
External IDs	OMIM: 607275 MGI: 1916782 HomoloGene: 15859 GeneCards: HOPX
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q12 Start 56,647,988 bp[1] End 56,681,899 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 C3.3 Start 77,234,835 bp[2] End 77,262,968 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis human penis oral cavity skin of abdomen vulva right lung upper lobe of left lung gums body of tongue amniotic fluid Top expressed in right lung lobe left lung superior surface of tongue right ventricle left lung lobe esophagus interventricular septum corneal stroma hair follicle lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nucleus Biological process regulation of transcription by RNA polymerase II negative regulation of cell differentiation multicellular organism development regulation of transcription, DNA-templated transcription, DNA-templated trophectodermal cell differentiation chaperone-mediated protein complex assembly cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84525 74318 Ensembl ENSG00000171476 ENSMUSG00000059325 UniProt Q9BPY8 Q8R1H0 RefSeq (mRNA) NM_001145459 NM_001145460 NM_032495 NM_139211 NM_139212 NM_001159900 NM_001159901 NM_175606 RefSeq (protein) NP_001138931 NP_001138932 NP_115884 NP_631957 NP_631958 NP_001153372 NP_001153373 NP_783199 Location (UCSC) Chr 4: 56.65 – 56.68 Mb Chr 5: 77.23 – 77.26 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homeodomain-only protein is a protein that in humans is encoded by the HOPX gene.^[5] It is an important regulator of cardiac development^[6] and a marker of hippocampal neural stem cells.^[7][8]

Function

The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggested that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development.^[6] Multiple alternatively spliced transcript variants encoding the same protein have been observed, the full-length natures of only some have been determined.^[5]