HOXA11
Identifiers
Aliases	HOXA11, HOX1, HOX1I, RUSAT1, homeobox A11
External IDs	OMIM: 142958 MGI: 96172 HomoloGene: 4033 GeneCards: HOXA11
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p15.2 Start 27,181,157 bp[1] End 27,185,232 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 B3|6 25.4 cM Start 52,219,086 bp[2] End 52,222,790 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in myometrium canal of the cervix stromal cell of endometrium transverse colon prostate urinary bladder cervix epithelium gastrocnemius muscle Achilles tendon vagina Top expressed in uterus vas deferens elbow ankle joint cervix female urethra prostate ankle hand metanephros More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component transcription regulator complex protein-DNA complex nucleus nucleoplasm protein-containing complex Biological process cartilage development involved in endochondral bone morphogenesis skeletal system development proximal/distal pattern formation regulation of chondrocyte differentiation male gonad development regulation of transcription, DNA-templated organ induction anatomical structure morphogenesis embryonic digit morphogenesis transcription, DNA-templated single fertilization uterus development multicellular organism development positive regulation of transcription, DNA-templated branching involved in ureteric bud morphogenesis developmental growth embryonic limb morphogenesis positive regulation of chondrocyte differentiation spermatogenesis positive regulation of cell development regulation of gene expression embryonic skeletal joint morphogenesis metanephros development mesodermal cell fate specification dorsal/ventral pattern formation embryonic forelimb morphogenesis anterior/posterior pattern specification bone development regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3207 15396 Ensembl ENSG00000005073 ENSMUSG00000038210 UniProt P31270 P31311 RefSeq (mRNA) NM_005523 NM_010450 RefSeq (protein) NP_005514 NP_034580 Location (UCSC) Chr 7: 27.18 – 27.19 Mb Chr 6: 52.22 – 52.22 Mb PubMed search [3] [4]
Wikidata
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Homeobox protein Hox-A11 is a protein that in humans is encoded by the HOXA11 gene.^[5][6][7]

Function

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radioulnar synostosis with amegakaryocytic thrombocytopenia.^[7]