HOXB2
Identifiers
Aliases	HOXB2, HOX2, HOX2H, Hox-2.8, K8, homeobox B2
External IDs	OMIM: 142967 MGI: 96183 HomoloGene: 37584 GeneCards: HOXB2
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.32 Start 48,540,894 bp[1] End 48,545,109 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 59.85 cM Start 96,241,351 bp[2] End 96,244,838 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in seminal vesicula right uterine tube corpus epididymis caput epididymis left coronary artery gastric mucosa right coronary artery canal of the cervix renal medulla kidney Top expressed in somite seminal vesicula proximal tubule adrenal gland enteric nervous system medullary collecting duct kidney yolk sac dermis abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component nucleus nucleoplasm cytosol nuclear speck Biological process multicellular organism development regulation of transcription, DNA-templated blood circulation transcription, DNA-templated morphogenesis of an epithelial sheet anterior/posterior pattern specification dorsal/ventral pattern formation rhombomere 3 development rhombomere 4 development facial nerve structural organization embryonic skeletal system morphogenesis skeletal system morphogenesis neural nucleus development transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3212 103889 Ensembl ENSG00000173917 ENSMUSG00000075588 UniProt P14652 P0C1T1 RefSeq (mRNA) NM_002145 NM_134032 RefSeq (protein) NP_002136 NP_598793 Location (UCSC) Chr 17: 48.54 – 48.55 Mb Chr 11: 96.24 – 96.24 Mb PubMed search [3] [4]
Wikidata
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Homeobox protein Hox-B2 is a protein that in humans is encoded by the HOXB2 gene.^[5][6][7]

Function

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer.^[7]