HOXB7
Identifiers
Aliases	HOXB7, HHO.C1, HOX2, HOX2C, Hox-2.3, homeobox B7
External IDs	OMIM: 142962 MGI: 96188 HomoloGene: 55828 GeneCards: HOXB7
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.32 Start 48,607,232 bp[1] End 48,633,572 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 59.82 cM Start 96,177,449 bp[2] End 96,180,988 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis caput epididymis seminal vesicula renal medulla endometrium glomerulus metanephric glomerulus kidney tubule kidney rectum Top expressed in Hindgut neural tube intestinal villus proximal tubule allantois yolk sac sclerotome adrenal gland axial skeleton kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding protein binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Cellular component nucleus nucleoplasm cytosol nuclear body Biological process multicellular organism development embryonic skeletal system morphogenesis myeloid cell differentiation positive regulation of branching involved in ureteric bud morphogenesis regulation of transcription, DNA-templated transcription, DNA-templated anterior/posterior pattern specification transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3217 15415 Ensembl ENSG00000260027 ENSMUSG00000038721 UniProt P09629 P09024 RefSeq (mRNA) NM_004502 NM_010460 RefSeq (protein) NP_004493 NP_034590 Location (UCSC) Chr 17: 48.61 – 48.63 Mb Chr 11: 96.18 – 96.18 Mb PubMed search [3] [4]
Wikidata
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Homeobox protein Hox-B7 is a protein that in humans is encoded by the HOXB7 gene.^[5][6]

Function

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.^[7]

Interactions

HOXB7 has been shown to interact with PBX1^[8] and CREB-binding protein.^[9]