HOXC4
Identifiers
Aliases	HOXC4, HOX3, HOX3E, cp19, homeobox C4
External IDs	OMIM: 142974 MGI: 96195 HomoloGene: 8408 GeneCards: HOXC4
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 54,016,931 bp[1] End 54,056,030 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F3|15 58.08 cM Start 102,927,366 bp[2] End 102,945,278 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube vena cava renal medulla saphenous vein pons left uterine tube caput epididymis spinal ganglia tibial nerve cardia Top expressed in superior cervical ganglion dermis abdominal wall somite esophagus epididymis cumulus cell medullary collecting duct renal corpuscle brown adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding HMG box domain binding DNA binding protein binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding Cellular component nucleus Biological process multicellular organism development skeletal system development cartilage development regulation of transcription, DNA-templated embryonic organ morphogenesis transcription, DNA-templated anterior/posterior pattern specification transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II embryonic skeletal system morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3221 15423 Ensembl ENSG00000198353 ENSMUSG00000075394 UniProt P09017 Q86TF7 Q08624 RefSeq (mRNA) NM_153633 NM_014620 NM_013553 RefSeq (protein) NP_055435 NP_705897 NP_055435.2 NP_705897.1 NP_038581 Location (UCSC) Chr 12: 54.02 – 54.06 Mb Chr 15: 102.93 – 102.95 Mb PubMed search [3] [4]
Wikidata
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Homeobox protein Hox-C4 is a protein that in humans is encoded by the HOXC4 gene.^[5][6][7]

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons.^[7]