HOXD3
Identifiers
Aliases	HOXD3, HOX1D, HOX4, HOX4A, Hox-4.1, homeobox D3
External IDs	OMIM: 142980 MGI: 96207 HomoloGene: 5034 GeneCards: HOXD3
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q31.1 Start 176,136,612 bp[1] End 176,173,102 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 C3|2 44.13 cM Start 74,542,271 bp[2] End 74,578,786 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis germinal epithelium right uterine tube seminal vesicula caput epididymis sperm kidney myometrium stromal cell of endometrium left uterine tube Top expressed in ureteric bud medulla oblongata enteric nervous system wall of urinary bladder urethra male urethra ureter renal pelvis mucosa of urinary bladder Collecting duct of renal tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding protein binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component aggresome nucleoplasm nucleus nuclear body Biological process Notch signaling pathway glossopharyngeal nerve morphogenesis embryonic skeletal system morphogenesis multicellular organism development thyroid gland development cartilage development positive regulation of gene expression cell-matrix adhesion regulation of transcription, DNA-templated positive regulation of neuron differentiation transcription, DNA-templated anterior/posterior pattern specification transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3232 15434 Ensembl ENSG00000128652 ENSMUSG00000079277 UniProt P31249 P09027 RefSeq (mRNA) NM_006898 NM_010468 RefSeq (protein) NP_008829 NP_034598 Location (UCSC) Chr 2: 176.14 – 176.17 Mb Chr 2: 74.54 – 74.58 Mb PubMed search [3] [4]
Wikidata
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Homeobox protein Hox-D3 is a protein that in humans is encoded by the HOXD3 gene.^[5][6][7]

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes.^[7]