Hamdani, Hamadani, Hamedani or Hamadhani (Arabic: همذاني, Persian: همدانی) is an Arabic nisbah (attributive title) that denotes an origin from the Hamadan province of Iran. It is commonly used for Badi' al-Zaman al-Hamadani, but the many notable people with the surname include:

• Mihran-i Hamadani (died 633), Sasanian military officer
• Burayr ibn Khuzayr al-Hamadani (7th century), Qāriʾ, Tabi‘un, and companion of Ali
• Ibn al-Faqih al-Hamadhani (10th century), Persian historian and geographer
• Abd al-Jabbâr al-Hamadhânî (935–1025), Mu'tazilite theologian
• Baba Taher Oryan Hamadani (938–1021), Persian poet
• Badi' al-Zaman al-Hamadani (969–1007), Persian Arabic-language writer and poet
• Yusuf Hamadani (1062–1141), Persian Sufi master
• Ayn al-Quzat Hamadani (1098–1131), Persian judge, mystic, and philosopher
• Rashid-al-Din Hamadani (1247–1318), Persian statesman, historian and physician
• Mir Sayyid Ali Hamadani (1314–1384), Persian Sufi poet and scholar
• Moshfegh Hamadani (1914–2009), Jewish Iranian journalist and writer
• Yosef Hamadani Cohen (1916–2014), Iranian Chief Rabbi
• Hossein Noori Hamedani (born 1926), Iranian Twelver Shi'a Marja
• Hossein Hamadani (1951–2015), Iranian Revolutionary Guard commander
• Sattar Hamedani (born 1974), Iranian footballer
• Ameer Sabah Hussein Al-Hamadani (born 1988), Iraqi footballer
• Anwar Al-Hamadani, Iraqi television presenter