Holy Spirit National High School Paaralang Sekundarya ng Holy Spirit (Filipino)
Address
Sto. Ireneo St., Doña Juana Extension, Barangay Holy Spirit Quezon City , Metro Manila Philippines
Coordinates	14°41′23″N 121°04′50″E / 14.68979°N 121.08046°E / 14.68979; 121.08046
Information
Type	Public, National High School
Motto	Guiding students through Excellence
Established	2003
Principal	Dr. Arnel L. Cañero
Grades	7 to 12
Number of students	approx. 3000, called as Holysians
Language	English, Filipino
Color(s)	Green and White
Song	HSNHS School Hymn
Nickname	Holy Spirit, Annex
Publication	'HSNHS Voice' (English) Under Mr. Flor Abel Vilog 'Ang Anag-ag' (Tagalog) Under Mrs. Jenielyn T. Garalda
Affiliations	Division of City Schools-Quezon City
Website	www.facebook.com/HolySpiritNationalHighSchool/

Holy Spirit National High School (HSNHS) is a public high school located in Barangay Holy Spirit in Quezon City, Philippines. It was founded on 2003 as Commonwealth High School Holy Spirit Annex, the annex school of Commonwealth High School in Barangay Holy Spirit, Quezon City. In 2008, it was renamed as Holy Spirit National High School after getting its independence.

History

Holy Spirit National High School was founded because of the need to provide quality and accessible education to students of Barangay Holy Spirit. To deal with the rise of enrollees in Commonwealth High School, the local government came up with the proposal of putting up an annex in the said barangay.

The first batch of graduates was headed by Bryan Lloyd dela Rosa, class of 2006 valedictorian.