HOXA10
Identifiers
Aliases	HOXA10, HOX1, HOX1.8, HOX1H, PL, Homeobox A10
External IDs	OMIM: 142957 MGI: 96171 HomoloGene: 7365 GeneCards: HOXA10
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p15.2 Start 27,170,605 bp[1] End 27,180,261 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 B3|6 25.4 cM Start 52,208,177 bp[2] End 52,217,834 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in biceps brachii myometrium endometrium vastus lateralis muscle canal of the cervix muscle of leg gastrocnemius muscle triceps brachii muscle deltoid muscle Achilles tendon Top expressed in connecting tubule vas deferens Bowman's capsule hand proximal tubule elbow hip myometrium foot triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific histone deacetylase binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm transcription regulator complex nucleus Biological process skeletal system development proximal/distal pattern formation male gonad development regulation of transcription, DNA-templated transcription, DNA-templated single fertilization uterus development multicellular organism development embryonic limb morphogenesis spermatogenesis regulation of gene expression anterior/posterior pattern specification positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3206 15395 Ensembl ENSG00000253293 ENSMUSG00000000938 UniProt P31260 P31310 RefSeq (mRNA) NM_018951 NM_153715 NM_001122950 NM_008263 RefSeq (protein) NP_061824 NP_001116422 NP_032289 Location (UCSC) Chr 7: 27.17 – 27.18 Mb Chr 6: 52.21 – 52.22 Mb PubMed search [3] [4]
Wikidata
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Homeobox protein Hox-A10 is a protein that in humans is encoded by the HOXA10 gene.^[5][6][7]

Function

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described.^[7] Downregulation of HOXA10 is observed in the human and baboon decidua after implantation and this downregulation promotes trophoblast invasion by activating STAT3.^[8]

Interactions

Homeobox A10 has been shown to interact with PTPN6.^[9]