Hugh Heyne Smythe (August 19, 1913 – June 22, 1977) was an American author, sociologist, diplomat and professor. He was an authority on African anthropology and East Asian studies. He served as the United States Ambassador to Syria from 1965 to 1967 and United States Ambassador to Malta from 1967 to 1969.

Smythe was the tenth African-American U.S. ambassador and the first to a Middle Eastern country. His tenure coincided with the Six-Day War and the severing of diplomatic ties with the United States. He later became notorious for the "Smythe Telegram" that he wrote during the increasing tensions before the war, where he demanded that the U.S. return to a pro-Arab foreign policy and said that the U.S. should ignore previous promises to Israel that Egypt would not be allowed to ban Israeli ships from transiting the Straits of Tiran. He left the country on June 8, 1967.