ICAM5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BN3, 4OI9, 4OIA, 4OIB
Identifiers
Aliases	ICAM5, TLCN, TLN, intercellular adhesion molecule 5
External IDs	OMIM: 601852 MGI: 109430 HomoloGene: 2447 GeneCards: ICAM5
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 10,289,952 bp[1] End 10,296,778 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A3|9 7.7 cM Start 20,943,369 bp[2] End 20,950,332 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex cingulate gyrus nucleus accumbens dorsolateral prefrontal cortex Brodmann area 9 caudate nucleus frontal pole hippocampus proper middle frontal gyrus amygdala Top expressed in entorhinal cortex superior frontal gyrus hippocampus proper Region I of hippocampus proper nucleus accumbens prefrontal cortex amygdala cingulate gyrus primary motor cortex subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function integrin binding protein binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process cell adhesion phagocytosis regulation of immune response extracellular matrix organization cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7087 15898 Ensembl ENSG00000105376 ENSMUSG00000032174 UniProt Q9UMF0 Q60625 RefSeq (mRNA) NM_003259 NM_008319 RefSeq (protein) NP_003250 NP_032345 Location (UCSC) Chr 19: 10.29 – 10.3 Mb Chr 9: 20.94 – 20.95 Mb PubMed search [3] [4]
Wikidata
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Intercellular adhesion molecule 5 is a protein that in humans is encoded by the ICAM5 gene.^[5][6][7]

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases.^[7]

Interactions

ICAM5 has been shown to interact with PSEN1.^[8]