ICE in the context of chemotherapy is an acronym for one of the chemotherapy regimens, used in salvage treatment of relapsed or refractory non-Hodgkin's lymphoma and Hodgkin lymphoma.
In case of CD20-positive B cell lymphoid malignancies the ICE regimen is often combined today with rituximab. This regimen is then called ICE-R or R-ICE or RICE.
[R]-ICE regimen consists of:[citation needed]
Drug | Dose | Mode | Days |
---|---|---|---|
Rituximab | 375 mg/m2 | IV infusion | Day 1 |
Ifosfamide | 5000 mg/m2 | IV continuous infusion over 24 hours | Day 2 |
Mesna for haemorrhagic cystitis prophylaxis with ifosfamide | 5000 mg/m2 | IV continuous infusion over 24 hours | Day 2 |
Carboplatin | Optimized to get AUC = 5 (max. 800 mg) | IV infusion | Day 2 |
Etoposide | 100 mg/m2 | IV infusion over 1 hour | Days 1-3 |
Filgrastim to shorten the period of neutropenia | 5 μg/kg | S.C. | Days 5-12 |
Cycles are repeated every 14 days for 3 cycles, then high-dose chemotherapy with autologous stem-cell transplantation follows (if the patient is considered eligible for HDCT and ASCT).[1][2]