ID3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LFH
Identifiers
Aliases	ID3, HEIR-1, bHLHb25, inhibitor of DNA binding 3, HLH protein
External IDs	OMIM: 600277 MGI: 96398 HomoloGene: 1633 GeneCards: ID3
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.12 Start 23,557,926 bp[1] End 23,559,501 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D3|4 68.34 cM Start 135,870,808 bp[2] End 135,873,066 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland left lobe of thyroid gland ascending aorta right coronary artery popliteal artery left coronary artery left uterine tube gastric mucosa pituitary gland fundus Top expressed in otic placode endocardial cushion body of femur medullary collecting duct hand seminal vesicula optic nerve molar calvaria maxillary prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein dimerization activity leptomycin B binding transcription corepressor activity protein domain specific binding DNA-binding transcription factor activity transcription factor binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nucleus Biological process negative regulation of myoblast differentiation regulation of transcription, DNA-templated epithelial cell differentiation rhythmic process regulation of DNA replication muscle organ development notochord development negative regulation of transcription by RNA polymerase II negative regulation of DNA-binding transcription factor activity negative regulation of osteoblast differentiation transcription, DNA-templated negative regulation of gene expression regulation of cell cycle odontogenesis multicellular organism development heart development central nervous system development response to wounding circadian rhythm neuron differentiation positive regulation of apoptotic process metanephros development negative regulation of transcription, DNA-templated cellular response to leptomycin B negative regulation of DNA binding negative regulation of neuron differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3399 15903 Ensembl ENSG00000283060 ENSG00000117318 ENSMUSG00000007872 UniProt Q02535 P41133 RefSeq (mRNA) NM_002167 NM_008321 RefSeq (protein) NP_002158 NP_032347 Location (UCSC) Chr 1: 23.56 – 23.56 Mb Chr 4: 135.87 – 135.87 Mb PubMed search [3] [4]
Wikidata
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DNA-binding protein inhibitor ID-3 is a protein that in humans is encoded by the ID3 gene.^[5][6]

Function

Members of the ID family of helix-loop-helix (HLH) proteins lack a basic DNA-binding domain and inhibit transcription through formation of nonfunctional dimers that are incapable of binding to DNA.[supplied by OMIM]^[6]

Interactions

ID3 (gene) has been shown to interact with TCF3.^[7][8]

Repressors of ID3

BTG2 binds to the promoter of Id3 and represses its activity. By this mechanism, the upregulation of Id3 in the hippocampus caused by BTG2 ablation prevents terminal differentiation of hippocampal neurons.^[9]