IFNA13

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
3UX9

Identifiers

Aliases

IFNA13, interferon alpha 13

External IDs

OMIM: 147578 HomoloGene: 136811 GeneCards: IFNA13

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	9p21.3	Start	21,367,424 bp^[1]
Band	9p21.3	End	21,368,962 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

corpus callosum

putamen

caudate nucleus

Brodmann area 9

amygdala

hippocampus proper

gastric mucosa

stromal cell of endometrium

substantia nigra

superior frontal gyrus

n/a

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	cytokine activity type I interferon receptor binding cytokine receptor binding
Cellular component	extracellular region extracellular space
Biological process	natural killer cell activation involved in immune response B cell differentiation defense response B cell proliferation blood coagulation positive regulation of peptidyl-serine phosphorylation of STAT protein humoral immune response adaptive immune response defense response to virus type I interferon signaling pathway response to exogenous dsRNA T cell activation involved in immune response cytokine-mediated signaling pathway innate immune response regulation of signaling receptor activity
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3447


n/a

Ensembl


ENSG00000233816


n/a

UniProt


P01562


n/a

RefSeq (mRNA)


NM_006900


n/a

RefSeq (protein)


NP_076918


n/a

Location (UCSC)

Chr 9: 21.37 – 21.37 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Interferon alpha-1/13, also known as IFN-alpha-1/13, is a protein that in humans is encoded by the IFNA1 and IFNA13 genes.^[3]^[4]

References

Nyman TA, Tölö H, Parkkinen J, Kalkkinen N (1998). "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes". Biochem. J. 329 (2): 295–302. doi:10.1042/bj3290295. PMC 1219044. PMID 9425112.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496. S2CID 11183658.
Weber H, Weissmann C (1983). "Formation of genes coding for hybrid proteins by recombination between related, cloned genes in E. coli". Nucleic Acids Res. 11 (16): 5661–9. doi:10.1093/nar/11.16.5661. PMC 326304. PMID 6310510.
Lamesch P, Li N, Milstein S, Fan C, Hao T, Szabo G, Hu Z, Venkatesan K, Bethel G (2007). "hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes". Genomics. 89 (3): 307–15. doi:10.1016/j.ygeno.2006.11.012. PMC 4647941. PMID 17207965.
Goeddel DV, Leung DW, Dull TJ, Gross M, Lawn RM, McCandliss R, Seeburg PH, Ullrich A, Yelverton E (1981). "The structure of eight distinct cloned human leukocyte interferon cDNAs". Nature. 290 (5801): 20–6. Bibcode:1981Natur.290...20G. doi:10.1038/290020a0. PMID 6163083. S2CID 1900300.
Myers MP, Andersen JN, Cheng A, Tremblay ML, Horvath CM, Parisien JP, Salmeen A, Barford D, Tonks NK (2001). "TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B". J. Biol. Chem. 276 (51): 47771–4. doi:10.1074/jbc.C100583200. PMID 11694501.
Hussain M, Ni D, Gill D, Liao MJ (2000). "IFN-alpha1a gene is the major variant in the North American population". J. Interferon Cytokine Res. 20 (9): 763–8. doi:10.1089/10799900050151021. PMID 11032395.
Humphray SJ, Oliver K, Hunt AR, Plumb RW, Loveland JE, Howe KL, Andrews TD (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Siezen CL, Bont L, Hodemaekers HM, Ermers MJ, Doornbos G, Van't Slot R, Wijmenga C, Houwelingen HC, Kimpen JL, Kimman TG, Hoebee B, Janssen R (2009). "Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes". Pediatr. Infect. Dis. J. 28 (4): 333–5. doi:10.1097/INF.0b013e31818e2aa9. PMID 19258923. S2CID 25601837.
Hardy MP, Owczarek CM, Jermiin LS, Ejdebäck M, Hertzog PJ (2004). "Characterization of the type I interferon locus and identification of novel genes". Genomics. 84 (2): 331–45. doi:10.1016/j.ygeno.2004.03.003. PMID 15233997.
Silva LK, Blanton RE, Parrado AR, Melo PS, Morato VG, Reis EA, Dias JP, Castro JM, Vasconcelos PF (2010). "Dengue hemorrhagic fever is associated with polymorphisms in JAK1". Eur. J. Hum. Genet. 18 (11): 1221–7. doi:10.1038/ejhg.2010.98. PMC 2950898. PMID 20588308.
Janssen R, Bont L, Siezen CL, Hodemaekers HM, Ermers MJ, Doornbos G, Slot Rv, Wijmenga C, Goeman JJ (2007). "Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes". J. Infect. Dis. 196 (6): 826–34. doi:10.1086/520886. PMID 17703412.
Shuai K, Horvath CM, Huang LH, Qureshi SA, Cowburn D, Darnell Jr JE (1994). "Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions". Cell. 76 (5): 821–8. doi:10.1016/0092-8674(94)90357-3. PMID 7510216. S2CID 41612814.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Sen GC, Lengyel P (1992). "The interferon system. A bird's eye view of its biochemistry". J. Biol. Chem. 267 (8): 5017–20. doi:10.1016/S0021-9258(18)42719-6. PMID 1371992.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tiefenbrun N, Melamed D, Levy N, Resnitzky D, Hoffman I, Reed SI, Kimchi A (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7): 3934–44. doi:10.1128/MCB.16.7.3934. PMC 231390. PMID 8668211.
Nagata S, Mantei N, Weissmann C (1980). "The structure of one of the eight or more distinct chromosomal genes for human interferon-alpha". Nature. 287 (5781): 401–8. Bibcode:1980Natur.287..401N. doi:10.1038/287401a0. PMID 6159536. S2CID 29500779.
Todokoro K, Kioussis D, Weissmann C (1984). "Two non-allelic human interferon alpha genes with identical coding regions". EMBO J. 3 (8): 1809–12. doi:10.1002/j.1460-2075.1984.tb02050.x. PMC 557600. PMID 6479148.
Schuurhof A, Bont L, Siezen CL, Hodemaekers H, Van Houwelingen HC, Kimman TG, Hoebee B, Kimpen JL, Janssen R (2010). "Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls". Pediatr. Pulmonol. 45 (6): 608–13. doi:10.1002/ppul.21229. PMID 20503287. S2CID 24678182.

IFNA13 is an interferon gene.

Cell signaling: cytokines

By family

Chemokine

CCL	CCL1 CCL2/MCP1 CCL3/MIP1α CCL4/MIP1β CCL5/RANTES CCL6 CCL7 CCL8 CCL9 CCL11 CCL12 CCL13 CCL14 CCL15 CCL16 CCL17 CCL18/PARC/DCCK1/AMAC1/MIP4 CCL19 CCL20 CCL21 CCL22 CCL23 CCL24 CCL25 CCL26 CCL27 CCL28
CXCL	CXCL1/KC CXCL2 CXCL3 CXCL4 CXCL5 CXCL6 CXCL7 CXCL8/IL8 CXCL9 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL15 CXCL16 CXCL17
CX3CL	CX3CL1
XCL	XCL1 XCL2

TNF

Interleukin

Type I
(grouped by
receptor
subunit)

γ chain	IL2/IL15 IL4/IL13 IL7 IL9 IL21
β chain	IL3 IL5 GMCSF
IL6 like/gp130	IL6 IL11 IL27 IL30 IL31 +non IL OSM LIF CNTF CTF1
IL12 family/IL12RB1	IL12 IL23 IL27 IL35
Other	IL14 IL16 IL32 IL34

Type II

IL10 family

IL10/IL22
IL19
IL20
IL24
IL26
Interferon type III
- IL28/IFNL2+3
- IL29/IFNL1

Interferon

I	IFNA1 IFNA2 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA21 IFNB1 IFNK IFNW1
II	IFNG

Ig superfamily

IL17 family

IL17/IL25 (IL17A)

Other

By function/
cell

proinflammatory cytokine
- IL1
- TNFA

Monokine
Lymphokine
- T_h1
  - IFNγ
  - TNFβ
- T_h2
  - IL4
  - IL5
  - IL6
  - IL10
  - IL13

Cytokine receptor modulators

Chemokine

See here instead.

CSF

Erythropoietin	Agonists: ARA-290 Asialo erythropoietin Carbamylated erythropoietin CNTO-530 Darbepoetin alfa Epoetin alfa Epoetin beta Epoetin delta Epoetin epsilon Epoetin gamma Epoetin kappa Epoetin omega Epoetin theta Epoetin zeta Erythropoietin (EPO) Erythropoietin-Fc Methoxy polyethylene glycol-epoetin beta (CERA/Mircera) Peginesatide Pegol sihematide (EPO-018B)
G-CSF (CSF3)	Agonists: Filgrastim Granulocyte colony-stimulating factor Lenograstim Leridistim Lipegfilgrastim Nartograstim Pegfilgrastim Pegnartograstim
GM-CSF (CSF2)	Agonists: Ecogramostim Granulocyte macrophage colony-stimulating factor Milodistim Molgramostim Regramostim Sargramostim Antibodies: Mavrilimumab Namilumab Otilimab
M-CSF (CSF1)	Agonists: Cilmostim Interleukin-34 Lanimostim Macrophage colony-stimulating factor Mirimostim Kinase inhibitors: Agerafenib
SCF (c-Kit)	See here instead.
Thrombopoietin	Agonists: Eltrombopag Pegacaristim Promegapoietin Romiplostim Thrombopoietin (THPO, MGDF)

Interferon

IFNAR (α/β, I)	Agonists: Albinterferon Interferon alpha (interferon alfa, IFN-α) Interferon alfa (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21) Interferon alfa 2a Interferon alfa 2b Interferon alfa n1 Interferon alfacon-1 Interferon alpha-n3 Interferon beta (IFN-β) (IFNB1, IFNB3) Interferon beta 1a Interferon beta 1b Interferon kappa (IFN-ε/κ/τ/ζ, IFNK) Interferon omega (IFN-ω, IFNW1) Peginterferon alfa-2a Peginterferon alfa-2b Antibodies: Anifrolumab Faralimomab MEDI-545 Rontalizumab Sifalimumab Decoy receptors: Bifarcept
IFNGR (γ, II)	Agonists: Interferon gamma (IFN-γ) Interferon gamma 1b Antibodies: Emapalumab Fontolizumab
IFNLR (λ, III)	See IL-28R (IFNLR) here instead.

Interleukin

See here instead.

TGFβ

See here instead.

TNF

See here instead.

Others

JAK
(inhibitors)

JAK1	Abrocitinib Baricitinib Filgotinib Momelotinib Oclacitinib Peficitinib Ruxolitinib Tofacitinib (tasocitinib) Upadacitinib
JAK2	Atiprimod AZD-1480 Baricitinib CHZ868 Cucurbitacin I (elatericin B, JSI-124) CYT387 Lestaurtinib NSC-7908 NSC-33994 Pacritinib Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib)
JAK3	Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib) WHI-P 154 ZM-39923 ZM-449829
TYK2	Deucravacitinib

Others

Additional cytokines: Cardiotrophin 1 (CT-1)
FMS-like tyrosine kinase 3 ligand (FLT3L)
Leukemia/leukocyte inhibitory factor (LIF)
Oncostatin M (OSM)
Thymic stromal lymphopoietin (TSLP)

Additional cytokine receptor modulators: Emfilermin
Lestaurtinib
Midostaurin
Quizartinib
Sorafenib
Sunitinib

References

Further reading