IFNAR2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIFNAR2, IFN-R, IFN-alpha-REC, IFNABR, IFNARB, IMD45, interferon alpha and beta receptor subunit 2
External IDsOMIM: 602376 MGI: 1098243 HomoloGene: 49242 GeneCards: IFNAR2
Orthologs
SpeciesHumanMouse
Entrez

3455

15976

Ensembl

ENSG00000159110

ENSMUSG00000022971

UniProt

P48551

O35664

RefSeq (mRNA)

NM_001110498
NM_010509
NM_001347258

RefSeq (protein)

NP_001103968
NP_001334187
NP_034639

Location (UCSC)Chr 21: 33.21 – 33.27 MbChr 16: 91.17 – 91.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interferon-alpha/beta receptor beta chain is a protein that in humans is encoded by the IFNAR2 gene.[5]

Function

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene.[6]

Interactions

IFNAR2 has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000159110 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022971 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Novick D, Cohen B, Rubinstein M (June 1994). "The human interferon alpha/beta receptor: characterization and molecular cloning". Cell. 77 (3): 391–400. doi:10.1016/0092-8674(94)90154-6. PMID 8181059. S2CID 140206806.
  6. ^ "Entrez Gene: IFNAR2 interferon (alpha, beta and omega) receptor 2".
  7. ^ a b Usacheva A, Smith R, Minshall R, Baida G, Seng S, Croze E, Colamonici O (June 2001). "The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor". J. Biol. Chem. 276 (25): 22948–53. doi:10.1074/jbc.M100087200. PMID 11301323.
  8. ^ Croze E, Usacheva A, Asarnow D, Minshall RD, Perez HD, Colamonici O (November 2000). "Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor". J. Immunol. 165 (9): 5127–32. doi:10.4049/jimmunol.165.9.5127. PMID 11046044.
  9. ^ Piehler J, Schreiber G (May 1999). "Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2". J. Mol. Biol. 289 (1): 57–67. doi:10.1006/jmbi.1999.2726. PMID 10339405.
  10. ^ a b Li X, Leung S, Kerr IM, Stark GR (April 1997). "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling". Mol. Cell. Biol. 17 (4): 2048–56. doi:10.1128/mcb.17.4.2048. PMC 232052. PMID 9121453.
  11. ^ Nguyen VP, Saleh AZ, Arch AE, Yan H, Piazza F, Kim J, Krolewski JJ (March 2002). "Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling". J. Biol. Chem. 277 (12): 9713–21. doi:10.1074/jbc.M111161200. PMID 11786546.

Further reading

Category