IL13RA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LB6
Identifiers
Aliases	IL13RA2, CD213A2, CT19, IL-13R, IL13BP, interleukin 13 receptor subunit alpha 2
External IDs	OMIM: 300130 MGI: 1277954 HomoloGene: 534 GeneCards: IL13RA2
Gene location (Human) Chr. X chromosome (human)[1] Band Xq23 Start 115,003,975 bp[1] End 115,019,977 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X F2|X 68.46 cM Start 146,166,472 bp[2] End 146,212,188 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm ascending aorta glomerulus metanephric glomerulus anterior pituitary islet of Langerhans hypothalamus nucleus accumbens synovial joint appendix Top expressed in cumulus cell pineal gland uterus lip ascending aorta aortic valve left colon interventricular septum ovary skin of abdomen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine receptor activity signal transducer activity protein binding cytokine binding Cellular component integral component of membrane membrane extracellular region extracellular space external side of plasma membrane receptor complex Biological process negative regulation of mast cell degranulation negative regulation of immunoglobulin production immunoglobulin mediated immune response cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3598 16165 Ensembl ENSG00000123496 ENSMUSG00000031289 UniProt Q14627 O88786 RefSeq (mRNA) NM_000640 NM_008356 NM_001306059 RefSeq (protein) NP_000631 NP_001292988 NP_032382 Location (UCSC) Chr X: 115 – 115.02 Mb Chr X: 146.17 – 146.21 Mb PubMed search [3] [4]
Wikidata
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Interleukin-13 receptor subunit alpha-2 (IL-13Rα2), also known as CD213A2 (cluster of differentiation 213A2), is a membrane bound protein that in humans is encoded by the IL13RA2 gene.^[5]

Function

IL-13Rα2 is closely related to IL-13Rα1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however, able to regulate the effects of both IL-13 and IL-4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13.^[5]

Clinical Significance

IL-13Rα2 has been found to be over-expressed in a variety of cancers, including pancreatic, ovarian, melanomas, and malignant gliomas. ^[6][7][8][9]