IL17RA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JVF, 4HSA, 4NUX
Identifiers
Aliases	IL17RA, CANDF5, CD217, CDw217, IL-17RA, IL17R, hIL-17R, interleukin 17 receptor A, IMD51
External IDs	OMIM: 605461 MGI: 107399 HomoloGene: 7378 GeneCards: IL17RA
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.1 Start 17,084,954 bp[1] End 17,115,693 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 F1|6 56.95 cM Start 120,440,208 bp[2] End 120,464,520 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood monocyte spongy bone bone marrow bone marrow cells internal globus pallidus secondary oocyte thymus pancreatic ductal cell inferior ganglion of vagus nerve Top expressed in blood thymus aortic valve ascending aorta spleen saccule secondary oocyte proximal tubule subcutaneous adipose tissue otic placode More reference expression data BioGPS More reference expression data
Gene ontology Molecular function interleukin-17 receptor activity signaling receptor binding protein binding Cellular component integral component of membrane extracellular region integral component of plasma membrane membrane plasma membrane Biological process positive regulation of cytokine production involved in inflammatory response cell surface receptor signaling pathway fibroblast activation positive regulation of inflammatory response granulocyte chemotaxis positive regulation of interleukin-23 production defense response to fungus cellular response to cytokine stimulus interleukin-17-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23765 16172 Ensembl ENSG00000177663 ENSMUSG00000002897 UniProt Q96F46 Q60943 RefSeq (mRNA) NM_014339 NM_001289905 NM_008359 RefSeq (protein) NP_001276834 NP_055154 NP_032385 Location (UCSC) Chr 22: 17.08 – 17.12 Mb Chr 6: 120.44 – 120.46 Mb PubMed search [3] [4]
Wikidata
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Interleukin 17 receptor A, also known as IL17RA and CDw217 (cluster of differentiation w217), is a human gene.^[5]

Interleukin 17A (IL17A)is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure.^[5]