IL2RB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B5I, 2ERJ, 3QAZ, 4GS7
Identifiers
Aliases	IL2RB, CD122, IL15RB, P70-75, interleukin 2 receptor subunit beta, IMD63
External IDs	OMIM: 146710 MGI: 96550 HomoloGene: 47955 GeneCards: IL2RB
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.3 Start 37,125,843 bp[1] End 37,175,054 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 E1|15 37.52 cM Start 78,363,456 bp[2] End 78,379,471 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood lymph node spleen appendix bone marrow cells mucosa of urinary bladder superficial temporal artery jejunal mucosa thymus gallbladder Top expressed in blood spleen secondary oocyte thymus pharynx subcutaneous adipose tissue submandibular gland duodenum bone marrow uterus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function interleukin-2 binding protein binding cytokine receptor activity interleukin-2 receptor activity interleukin-15 receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane external side of plasma membrane endosome cytosol interleukin-2 receptor complex cell surface Biological process negative regulation of apoptotic process MAPK cascade interleukin-2-mediated signaling pathway viral process signal transduction cytokine-mediated signaling pathway interleukin-15-mediated signaling pathway regulation of molecular function positive regulation of phagocytosis protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3560 16185 Ensembl ENSG00000100385 ENSMUSG00000068227 UniProt P14784 P16297 RefSeq (mRNA) NM_000878 NM_001346222 NM_001346223 NM_008368 RefSeq (protein) NP_000869 NP_001333151 NP_001333152 NP_032394 Location (UCSC) Chr 22: 37.13 – 37.18 Mb Chr 15: 78.36 – 78.38 Mb PubMed search [3] [4]
Wikidata
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Interleukin-2 receptor subunit beta is a protein that in humans is encoded by the IL2RB gene.^[5] Also known as CD122; IL15RB; P70-75.^[5]

Function

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit (also called CD25) and is not involved in signal transduction. The intermediate affinity form consists of a gamma/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein.^[5]

This protein also forms one of the three subunits of the IL-15 receptor.

Activation of the receptor increases proliferation of CD8+ effector T cells.^[6]

Interactions

IL2RB has been shown to interact with:

• CISH,^[7]
• HGS,^[8]
• Janus kinase 1,^{[9][10][11][12][13]} and
• SHC1.^[14][15]