IL36B
Identifiers
Aliases	IL36B, FIL1, FIL1-(ETA), FIL1H, FILI-(ETA), IL-1F8, IL-1H2, IL1-ETA, IL1F8, IL1H2, interleukin 36, beta, interleukin 36 beta
External IDs	OMIM: 605508 MGI: 1916927 HomoloGene: 18278 GeneCards: IL36B
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q14.1 Start 113,022,089 bp[1] End 113,052,867 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 A3|2 16.21 cM Start 24,043,173 bp[2] End 24,050,531 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen islet of Langerhans thymus stromal cell of endometrium vagina head mouth exocrine gland urinary bladder salivary gland Top expressed in esophagus lip cervix belly cord trachea skin of abdomen digastric muscle skin of back stomach ovary More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity interleukin-1 receptor binding Cellular component extracellular region extracellular space Biological process innate immune response inflammatory response immune response immune system process regulation of signaling receptor activity cytokine-mediated signaling pathway neutrophil chemotaxis positive regulation of interleukin-6 production positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of T cell differentiation positive regulation of JNK cascade cellular response to lipopolysaccharide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27177 69677 Ensembl ENSG00000136696 ENSMUSG00000026985 UniProt Q9NZH7 Q9D6Z6 RefSeq (mRNA) NM_014438 NM_173178 NM_027163 RefSeq (protein) NP_055253 NP_775270 NP_081439 Location (UCSC) Chr 2: 113.02 – 113.05 Mb Chr 2: 24.04 – 24.05 Mb PubMed search [3] [4]
Wikidata
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Interleukin-36 beta also known as interleukin-1 family member 8 (IL1F8) is a protein that in humans is encoded by the IL36B gene.^[5][6][7][8]

Function

The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.^[8]