IL3RA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4JZJ
Identifiers
Aliases	IL3RA, CD123, IL3R, IL3RAY, IL3RX, IL3RY, hIL-3Ra, interleukin 3 receptor subunit alpha
External IDs	OMIM: 308385, 430000 MGI: 96553 HomoloGene: 48088 GeneCards: IL3RA
Gene location (Human) Chr. X chromosome (human)[1] Band X;Y Start 1,336,616 bp[1] End 1,382,689 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 A1|14 7.08 cM Start 8,113,752 bp[2] End 8,123,488 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube upper lobe of left lung sural nerve left uterine tube gastric mucosa canal of the cervix left lobe of thyroid gland right lobe of thyroid gland subcutaneous adipose tissue lymph node Top expressed in yolk sac seminiferous tubule thymus spermatocyte lip islet of Langerhans lens morula ankle subcutaneous adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine receptor activity interleukin-3 receptor activity protein tyrosine kinase activity cytokine binding Cellular component integral component of membrane plasma membrane membrane intracellular anatomical structure external side of plasma membrane receptor complex Biological process MAPK cascade cellular response to interleukin-3 peptidyl-tyrosine phosphorylation interleukin-3-mediated signaling pathway cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3563 16188 Ensembl ENSG00000185291 ENSMUSG00000068758 UniProt P26951 P26952 RefSeq (mRNA) NM_001267713 NM_002183 NM_008369 RefSeq (protein) NP_001254642 NP_002174 NP_032395 Location (UCSC) Chr X: 1.34 – 1.38 Mb Chr 14: 8.11 – 8.12 Mb PubMed search [3] [4]
Wikidata
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Interleukin 3 receptor, alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123), is a human gene.^[5]

Function

The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y.^[5]

Interactions

IL3RA has been shown to interact with Interleukin 3.^[6][7]