INHA
Identifiers
Aliases	INHA, inhibin alpha subunit, inhibin subunit alpha
External IDs	OMIM: 147380 MGI: 96569 HomoloGene: 1652 GeneCards: INHA
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q35 Start 219,569,162 bp[1] End 219,575,711 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C4|1 39.16 cM Start 75,483,721 bp[2] End 75,487,010 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland left adrenal gland placenta nucleus accumbens body of pancreas anterior pituitary caudate nucleus putamen stromal cell of endometrium right lobe of thyroid gland Top expressed in cumulus cell ovary testicle seminiferous tubule superior frontal gyrus spermatocyte adrenal gland islet of Langerhans cerebellar cortex uterine tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity hormone activity protein binding protein heterodimerization activity transforming growth factor beta receptor binding growth factor activity signaling receptor binding inhibin binding Cellular component cytoplasm inhibin-betaglycan-ActRII complex photoreceptor inner segment photoreceptor outer segment extracellular region neuronal cell body inhibin A complex inhibin B complex extracellular space Biological process regulation of apoptotic process skeletal system development cell differentiation male gonad development regulation of MAPK cascade SMAD protein signal transduction cell development negative regulation of macrophage differentiation cell-cell signaling positive regulation of pathway-restricted SMAD protein phosphorylation negative regulation of cell cycle positive regulation of follicle-stimulating hormone secretion regulation of cell cycle cell surface receptor signaling pathway regulation of cell population proliferation hemoglobin biosynthetic process negative regulation of B cell differentiation ovarian follicle development erythrocyte differentiation negative regulation of follicle-stimulating hormone secretion negative regulation of phosphorylation signal transduction BMP signaling pathway regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3623 16322 Ensembl ENSG00000123999 ENSMUSG00000032968 UniProt P05111 Q04997 RefSeq (mRNA) NM_002191 NM_010564 NM_001329843 RefSeq (protein) NP_002182 NP_001316772 NP_034694 Location (UCSC) Chr 2: 219.57 – 219.58 Mb Chr 1: 75.48 – 75.49 Mb PubMed search [3] [4]
Wikidata
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Inhibin, alpha, also known as INHA, is a protein which in humans is encoded by the INHA gene.^[5]

Function

The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease.

However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.^[6]