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Ilaprazole
Clinical data
Trade namesNoltec
Routes of
administration		Oral
ATC code
  • None
Identifiers
  • 2-[(RS)-[(4-methoxy-3-methylpyridin-2-yl)methyl]sulfinyl]-5-(1H-pyrrol-1-yl)-1H-benzimidazole
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC19H18N4O2S
Molar mass366.44 g·mol−1
3D model (JSmol)
  • Cc1c(OC)ccnc1CS(=O)c2[nH]c3ccc(cc3n2)n4cccc4
  • InChI=1S/C19H18N4O2S/c1-13-17(20-8-7-18(13)25-2)12-26(24)19-21-15-6-5-14(11-16(15)22-19)23-9-3-4-10-23/h3-11H,12H2,1-2H3,(H,21,22)
  • Key:HRRXCXABAPSOCP-UHFFFAOYSA-N

Ilaprazole (trade name Noltec) is a proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD)[1] and duodenal ulcer.[2][3]

It is available in strengths of 5, 10, and 20 mg.

Clinical studies show that ilaprazole is at least as potent a PPI as omeprazole when taken in equivalent doses. Studies also showed that ilaprazole significantly prevented the development of reflux oesophagitis.

Ilaprazole is developed by Il-Yang Pharmaceutical (Korea), and is still under clinical trials with US FDA. It has launched in Korea and China for the treatment of gastric ulcer, duodenal ulcer, gastroesophageal reflux disease and erosive esophagitis.[4]

Ilaprazole is sold in Mexico by Chinoin Pharmaceuticals under the brand name Norutec.[5]

References

  1. ^ Savarino E, Ottonello A, Martinucci I, Dulbecco P, Savarino V (October 2016). "Ilaprazole for the treatment of gastro-esophageal reflux". Expert Opinion on Pharmacotherapy. 17 (15): 2107–13. doi:10.1080/14656566.2016.1232389. PMID 27598861. S2CID 38638311.
  2. ^ Bohidar NP, Krishna K, Panda BK, Patel C (2013). "Ilaprazole: Is this a superior proton pump inhibitor for duodenal ulcer?". Tropical Gastroenterology. 34 (2): 95–8. doi:10.7869/tg.2012.105. PMID 24377157.
  3. ^ Ji XQ, Du JF, Chen G, Chen G, Yu B (May 2014). "Efficacy of ilaprazole in the treatment of duodenal ulcers: a meta-analysis". World Journal of Gastroenterology. 20 (17): 5119–23. doi:10.3748/wjg.v20.i17.5119. PMC 4009550. PMID 24803828.
  4. ^ Clinical trial number NCT00952978 for "Ilaprazole for the Treatment of Duodenal Ulcer in Chinese Patients (Phase 3)" at ClinicalTrials.gov
  5. ^ "Norutec". Chinoin Pharmaceuticals.
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