People

Issa (name), a given name and surname
Kobayashi Issa (1763–1828), a Japanese poet
Issa or Isa, the Arabic name for Jesus in Islam
Issa, another name for the Native American Catawba people
El-Issa family
Issa (clan), a Somali clan that mainly inhabits Djibouti
Jane Siberry (born 1955), Canadian singer who released several albums under the name Issa
Issa, the nickname of Luttif Afif, a leader of the Black September terror squad at the 1972 Olympic Games

Places

Issa (polis), the Ancient Greek and Roman name for both the town of Vis and the Adriatic island of Vis, in modern-day Croatia
Issa (Lesbos) (Ἴσσα), ancient town of Lesbos, Greece, formerly applied to the island as well
Issa (inhabited locality) (Исса), several inhabited localities in Russia
- Issa, Penza Oblast
- Issa, Pskov Oblast
Issa, Polish spelling of Isa (river) (Belarusian: Іса)

Independent Schools Sports Association, now known as the Sports Association for Adelaide Schools
Information Systems Security Association
Instituto Superior de Secretariado y Administracion (ISSA), a center of the University of Navarra that trains elite management assistants
International Sailing Schools Association, an international association of sailing schools
International Sanamahism Students' Association, Kangleipak, an international association of the students of a traditional Meitei religion
International Securities Services Association, an association of securities services providers; see Borsa Istanbul
International Social Security Association, headquartered in Geneva, Switzerland
International Sports Sciences Association, an international organization of fitness experts which certifies personal fitness trainers
International Ship Suppliers Association
International Strategic Studies Association
Interscholastic Sailing Association
Irish Seed Savers Association

Issa (moth), a moth genus
Issa Album, 2017 album by 21 Savage
Issa (Belgariad), a divine character in David Eddings's fantasy series The Belgariad and The Malloreon